methyl 2-(pyrimidin-2-ylthio)acetate

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: methyl 2-(pyrimidin-2-ylthio)acetate
• 英文别名: Methyl 2-pyrimidin-2-ylsulfanylacetate
• 化学式: C₇H₈N₂O₂S
• mdl: MFCD06079415
• 分子量: 184.219
• InChiKey: KDMAIASKHFILKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  77.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  溴乙酸甲酯 、 2-巯基嘧啶 在 三乙胺 作用下， 以 乙腈 为溶剂， 生成 methyl 2-(pyrimidin-2-ylthio)acetate
  参考文献：
  名称：

  2-Pyrimidine Thioesters and Thiocarbonates as Skin Brightening Agents

  摘要：

  2-嘧啶硫酯和硫代碳酸酯被披露为有效的皮肤美白剂。这些化合物可以与皮肤学上可接受的载体配制成皮肤美白组合物。还披露了使用这些剂来美白皮肤和抑制黑色素生成的方法。

  公开号：

  US20130273183A1

文献信息

• ANTI-PENICILLIN RESISTANT PNEUMOCOCCI AGENT AND NOVEL 16-MEMBERED RING MACROLIDE DERIVATIVE
  申请人：Microbial Chemistry Research Foundation

  公开号：EP1849796B1

  公开（公告）日：2014-11-05
• Anti-Penicillin Resistant Pneumococci Agent and Novel 16-Membered Macrolide Derivative
  申请人：Miyake Toshiaki

  公开号：US20080300388A1

  公开（公告）日：2008-12-04

  A novel compound that has antimicrobial activity against penicillin-resistant Streptococcus pneumoniae , and an anti-penicillin resistant pneumococci agent that includes the compound as an active ingredient are provided. Thus, an anti-penicillin resistant pneumococci agent is provided that includes as an active ingredient a compound represented by the following formula (I) or a pharmacologically acceptable salt thereof, or hydrates thereof: wherein, in the formula (I), R represents any one of a halogen atom, an azido group, Ra-Wa-, Rb-Wb-, Rc-Wc-, and RdRd′N—.
• US8053418B2
  申请人：——

  公开号：US8053418B2

  公开（公告）日：2011-11-08
• US8507453B2
  申请人：——

  公开号：US8507453B2

  公开（公告）日：2013-08-13
• [EN] 2-PYRIMIDINE THIOESTERS AND THIOCARBONATES AS SKIN BRIGHTENING AGENTS<br/>[FR] 2-PYRIMIDINE THIOESTERS ET THIOCARBONATES UTILISÉS EN TANT QU'AGENTS ÉCLAIRCISSANT LA PEAU
  申请人：EASTMAN CHEM CO

  公开号：WO2013154832A2

  公开（公告）日：2013-10-17

  2-Pyrimidine thioesters and thiocarbonates are disclosed as effective skin brightening agents. These compounds may be formulated with dermatologically acceptable carriers to form skin brightening compositions. Methods for brightening skin and for inhibiting melanogenesis using these agents are also disclosed.