N-isopropyl-N'-(1-phenylethyl)urea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-isopropyl-N'-(1-phenylethyl)urea
• 英文别名: 1-(1-Phenylethyl)-3-propan-2-ylurea
• 化学式: C₁₂H₁₈N₂O
• 分子量: 206.288
• InChiKey: UTFPHAVVQBCPNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  α-苯乙胺 、 异氰酸异丙酯 以 二氯甲烷 为溶剂， 反应 2.0h， 以94%的产率得到N-isopropyl-N'-(1-phenylethyl)urea
  参考文献：
  名称：

  ROMPGEL Scavengers:  A High-Loading Supported Anhydride for Sequestering Amines and Hydrazines

  摘要：

  [GRAPHICS]A versatile method for sequestering excess amines and hydrazines is reported using a high loading ROMPGEL anhydride polymer.

  DOI：

  10.1021/ol006191s

文献信息

• α-Haloalkyl Haloformates and Related Compounds 3.¹A Facile Synthesis of Symmetrical and Unsymmetrical Ureas<i>via</i>Chloromethyl Carbamates
  作者：Tamás Patonay、Erzsébet Patonay-Péli、László Zolnai、Ferenc Mogyoródi

  DOI：10.1080/00397919608004663

  日期：1996.11

  Abstract Chloromethyl carbamates were prepared by the reaction of chloromethyl chloroformates with amines and found to produce mono-, symmetrically or unsymmetrically di-and trisubstituted ureas including their N-hydroxy and N-alkoxy derivatives in moderate to good yield.

  摘要 氨基甲酸氯甲酯是通过氯甲酸氯甲酯与胺反应制备的，并发现可以以中等至良好的收率生产单、对称或不对称双和三取代的脲，包括它们的 N-羟基和 N-烷氧基衍生物。
• Benzimidazole derivatives
  申请人：Frenkel David Alexander

  公开号：US20070037803A1

  公开（公告）日：2007-02-15

  Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related conditions or disorders. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, immune response regulation and cell proliferation. The subject compounds are 2-amino-imidazole derivatives.

  本发明提供了一种用于治疗炎症和免疫相关疾病或疾病的化合物、药物组合物和方法。特别地，本发明提供了调节参与炎症、免疫反应调节和细胞增殖的蛋白质的表达和/或功能的化合物。所述化合物为2-氨基咪唑衍生物。
• BENZIMIDAZOLE DERIVATIVES
  申请人：Frenkel Alexander David

  公开号：US20100048565A1

  公开（公告）日：2010-02-25

  Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related conditions or disorders. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, immune response regulation and cell proliferation. The subject compounds are 2-amino-imidazole derivatives.

  本发明提供了在治疗炎症和免疫相关的疾病或疾病中有用的化合物、制药组合物和方法。特别地，本发明提供了能够调节参与炎症、免疫反应调节和细胞增殖的蛋白质的表达和/或功能的化合物。这些化合物是2-氨基咪唑衍生物。
• US7635774B2
  申请人：——

  公开号：US7635774B2

  公开（公告）日：2009-12-22
• ROMPGEL Scavengers:  A High-Loading Supported Anhydride for Sequestering Amines and Hydrazines
  作者：Thomas Arnauld、Anthony G. M. Barrett、Susan M. Cramp、Richard S. Roberts、Frederic J. Zécri

  DOI：10.1021/ol006191s

  日期：2000.8.1

  [GRAPHICS]A versatile method for sequestering excess amines and hydrazines is reported using a high loading ROMPGEL anhydride polymer.