8-benzenesulfonyl-6,7-difluoro-4-methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 8-benzenesulfonyl-6,7-difluoro-4-methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine
• 英文别名: 8-(benzenesulfonyl)-6,7-difluoro-4-methyl-2,3-dihydro-1H-pyrido[2,3-b]pyrazine
• 化学式: C₁₄H₁₃F₂N₃O₂S
• 分子量: 325.339
• InChiKey: COSVHDIMFIUMOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  70.7
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  五氟吡啶 在 碳酸氢钠 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 22.0h， 生成 8-benzenesulfonyl-6,7-difluoro-4-methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine
  参考文献：
  名称：

  Polyfunctional Tetrahydropyrido[2,3-b]pyrazine Scaffolds from 4-Phenylsulfonyl Tetrafluoropyridine

  摘要：

  Polyfunctional tetrahydropyrido[2,3-b]pyrazine scaffolds can be synthesized by sequential reaction of pentafluoropyridine with sodium phenylsulfinate and an appropriate diamine. The polyfunctionality possessed by the difluorinated tetrahydropyrido [2,3-b] pyrazine scaffolds was demonstrated in selected model reactions with nucleophiles to give access to various polysubstituted [6,6]-ring fused systems.

  DOI：

  10.1021/jo051453v

文献信息

• Polyfunctional Tetrahydropyrido[2,3-<i>b</i>]pyrazine Scaffolds from 4-Phenylsulfonyl Tetrafluoropyridine
  作者：Aurelie Baron、Graham Sandford、Rachel Slater、Dmitry S. Yufit、Judith A. K. Howard、Antonio Vong

  DOI：10.1021/jo051453v

  日期：2005.11.1

  Polyfunctional tetrahydropyrido[2,3-b]pyrazine scaffolds can be synthesized by sequential reaction of pentafluoropyridine with sodium phenylsulfinate and an appropriate diamine. The polyfunctionality possessed by the difluorinated tetrahydropyrido [2,3-b] pyrazine scaffolds was demonstrated in selected model reactions with nucleophiles to give access to various polysubstituted [6,6]-ring fused systems.