S-(m-tolyl) O,O-dipropyl thiophosphate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: S-(m-tolyl) O,O-dipropyl thiophosphate
• 英文别名: di-n-propyl (3-methylphenylthio)phosphonate；1-Dipropoxyphosphorylsulfanyl-3-methylbenzene；1-dipropoxyphosphorylsulfanyl-3-methylbenzene
• 化学式: C₁₃H₂₁O₃PS
• 分子量: 288.348
• InChiKey: IKLKLWFWBYRRJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  60.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-甲基苯硫酚 、 亚磷酸酯二正丙脂 在 1,3-二氯-5,5-二甲基海因 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 以90%的产率得到S-(m-tolyl) O,O-dipropyl thiophosphate
  参考文献：
  名称：

  DCDMH-promoted synthesis of thiophosphates by coupling of H-phosphonates with thiols

  摘要：

  DCDMH-mediated phosphorylation of versatile thiols with H-phosphonates for the preparation of synthetically and biologically important thiophosphates was demonstrated. Without metal catalysts and other additives, phosphorylation occurred to give the desired products with good to excellent yields within 10 min at ambient temperature in the air. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.12.020

文献信息

• DCDMH-promoted synthesis of thiophosphates by coupling of H-phosphonates with thiols
  作者：Xiaojing Bi、Junchen Li、Fanhua Meng、Hongmei Wang、Junhua Xiao

  DOI：10.1016/j.tet.2015.12.020

  日期：2016.2

  DCDMH-mediated phosphorylation of versatile thiols with H-phosphonates for the preparation of synthetically and biologically important thiophosphates was demonstrated. Without metal catalysts and other additives, phosphorylation occurred to give the desired products with good to excellent yields within 10 min at ambient temperature in the air. (C) 2015 Elsevier Ltd. All rights reserved.