undecyldimethylphosphine oxide

• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机膦及其衍生物
• 英文名称: undecyldimethylphosphine oxide
• 英文别名: n-Undecyl-dimethylphosphine oxide；1-dimethylphosphorylundecane
• 化学式: C₁₃H₂₉OP
• 分子量: 232.346
• InChiKey: MQRSERQKFMSXRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-氯十一烷 、 二甲基氧化膦 在 sodium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 16.25h， 以92%的产率得到undecyldimethylphosphine oxide
  参考文献：
  名称：

  改进的合成路线，以实现异效烷基膦氧化物

  摘要：

  为杂烷基膦氧化物的合成的新方法（R 2 - [R 1 P = O，其中R≠ - [R 1）从仲膦氧化物（或战略性计划目标，R 2 HP═O）被呈现。这些反应在室温下快速，空间选择性，高产率，并且在水洗后纯度> 95％。SPO的去质子化反应生成次膦酸酯阴离子（[R 2 P–O] -），该阴离子对烷基卤与亲核P–C键的形成具有很高的选择性（与O–C键的形成相反）。出乎意料的是，大多数强有机金属碱都无法将SPO脱质子化为其各自的次膦酸酯阴离子（p K a大多数SPO的s <27）。仅双（三甲基甲硅烷基）酰胺钠（NaHMDS）干净地形成亚膦酸酯阴离子，该亚膦酸酯阴离子在溶液中（0.1 M，在THF中为23°C）稳定24小时以上。需要非常特异的碱去质子化提示离子配对和共轭酸都在稳定次膦酸酯阴离子中起作用。次膦酸酯阴离子的反应性遵循与烷基卤化物反应的S N 2机理的预期趋势。从来没有观察到消除产品。以

  DOI：

  10.1021/acs.organomet.7b00304

文献信息

• Photoprotection compositions comprising sorbohydroxamic acid
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0313302A2

  公开（公告）日：1989-04-26

  Disclosed are pharmaceutical compositions comprising sorbohydroxamic acid, or pharmaceutically-acceptable salts thereof, which are useful for topical application to prevent damage to skin caused by acute or chronic UV exposure. Combinations of sorbohydroxamic acid together with tocopherol sorbate and/or sunscreens are also disclosed. Also disclosed is a method for using these compositions topically, prior to UV exposure, to prevent damage to skin caused by acute or chronic UV exposure.

  公开了包含山梨醇羟肟酸或其药学上可接受的盐类的药物组合物，这些组合物可用于局部应用，以防止急性或慢性紫外线照射对皮肤造成的损害。还公开了山梨醇羟肟酸与生育酚山梨酸酯和/或防晒剂的组合。 还公开了在紫外线照射前局部使用这些组合物以防止急性或慢性紫外线照射对皮肤造成损害的方法。
• Photoprotection compositions comprising tocopherol sorbate
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0313304A2

  公开（公告）日：1989-04-26

  Disclosed are pharmaceutical compositions comprising toco­pherol sorbate which are useful for topical application to prevent damage to skin caused by acute or chronic UV exposure. Combina­tions of tocopherol sorbate and sunscreening agents are also disclosed. Also disclosed is a method for using these compositions topically, to prevent damage to skin caused by acute or chronic UV exposure.

  本发明公开了含有生育酚山梨酸酯的药物组合物，该组合物可用于局部使用，以防止急性或慢性紫外线照射对皮肤造成的损伤。还公开了生育酚山梨酸酯和防晒剂的组合物。 还公开了一种局部使用这些组合物的方法，以防止急性或慢性紫外线照射对皮肤造成的损害。
• Photoprotection compositions comprising chelating agents
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0313305A2

  公开（公告）日：1989-04-26

  The present invention involves photoprotective compositions which are useful for topical application to prevent damage to skin caused by acute or chronic exposure to ultraviolet light comprising chelating agents. Also involved are compositions comprising chelating agents together with anti-inflammatory agents, sunscreening agents, and/or radical scavenging agents. Methods for using such compositions to prevent damage to skin caused by acute or chronic exposure to ultraviolet light are also involved.

  本发明涉及光保护组合物，该组合物可用于局部使用，以防止皮肤因急性或慢性紫外线照射而受损，其中包含螯合剂。本发明还涉及包含螯合剂和消炎剂、防晒剂和/或自由基清除剂的组合物。还涉及使用此类组合物防止皮肤因急性或慢性紫外线照射而受损的方法。
• Photoprotection compositions comprising sorbohydroxamic acid and an anti-inflammatory agent
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0313347A2

  公开（公告）日：1989-04-26

  Disclosed are pharmaceutical compositions comprising sorbohydroxamic acid, or pharmaceutically-acceptable salts thereof, and an anti-inflammatory agent, which are useful for topical application to prevent damage to skin caused by acute or chronic UV exposure. Combinations of sorbohydroxamic acid and an anti-inflammatory agent together with tocopherol sorbate and/or sunscreens are also disclosed. Also disclosed is a method for using these compositions topically to prevent damage to skin caused by acute or chronic UV exposure.

  本发明公开了由山梨醇羟肟酸或其药学上可接受的盐类和一种抗炎剂组成的药物组合物，该组合物可用于局部使用，以防止急性或慢性紫外线照射对皮肤造成的损伤。还公开了山梨醇羟肟酸和消炎剂与生育酚山梨酸酯和/或防晒剂的组合。 还公开了一种局部使用这些组合物的方法，以防止急性或慢性紫外线照射对皮肤造成的损害。
• Carrier based on granules produced from pyrogenically prepared silicon dioxides
  申请人：Neugebauer Peter

  公开号：US20060229210A1

  公开（公告）日：2006-10-12

  Carrier based on granules produced from pyrogenically prepared silicon dioxides. The use of granules produced from pyrogenically prepared silicon dioxides as carriers for substances including foodstuffs additives, such as dyestuffs, antioxidants, preservatives, emulsifiers, gelling agents, thickeners and binders, stabilizers, alkalis, acids, salts, antilumping agents, flavour intensifiers, sweeteners, aromas; feedstuff additives; chemical intermediates and plant protection agents.

  基于热原制备的二氧化硅颗粒的载体。利用热致制备的二氧化硅生产的颗粒作为载体，用于载入各种物质，包括食品添加剂，如染料、抗氧化剂、防腐剂、乳化剂、胶凝剂、增稠剂和粘合剂、稳定剂、碱、酸、盐、防结块剂、增味剂、甜味剂、芳香剂；饲料添加剂；化学中间体和植物保护剂。