噻吩-3-基甲基乙酸酯 | 98277-70-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 中文名称: 噻吩-3-基甲基乙酸酯
• 英文名称: thiophen-3-ylmethyl acetate
• CAS: 98277-70-4
• 化学式: C₇H₈O₂S
• 分子量: 156.205
• InChiKey: FSBJKTNGHBWYNC-UHFFFAOYSA-N

物化性质

• 沸点：
  105.5 °C(Press: 16 Torr)
• 密度：
  1.174 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  54.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  噻吩-3-基甲基乙酸酯 在 sodium hydroxide 作用下， 生成 3-噻吩甲醇
  参考文献：
  名称：

  6-Phenylthieno[2,3-b]pyridine from 2-Nitro-3-thenaldehyde

  摘要：

  DOI：

  10.1021/ja01571a048
• 作为产物：
  描述：

  3-噻吩甲醛 在 4-二甲氨基吡啶 、 lithium aluminium tetrahydride 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 4.0h， 生成 噻吩-3-基甲基乙酸酯
  参考文献：
  名称：

  Tetrathiafulvalene (TTF)-Functionalized Thiophene Copolymerized with 3,3‴-Didodecylquaterthiophene: Synthesis, TTF Trapping Activity, and Response to Trinitrotoluene

  摘要：

  We report a synthesis route to a thiophene polymer where the repeat unit consists of 3,3'''-didodecylquaterthiophene (as in PQT12) plus an additional thiophene ring from which other functional groups may be projected. The hydroxymethyl form of this polymer, while only a poor semiconductor in its own right, serves as a vehicle for compatibilizing PQT12 itself with arbitrary functional groups. In this article, we focus on tetrathiafulvalene (TTF) as the functionality. As expected, the TTF group acts as a hole trap, as shown by loss of hole mobility and a surprising negative Seebeck coefficient, but this enables a current-increase response to trinitrotoluene as an analyte and confirms a similar observation we recently reported for a dissolved TTF. Added dopants also fill the trap states, restoring hole mobility and the typical positive Seebeck coefficient.

  DOI：

  10.1021/ma3019365

文献信息

• An Amino Alcohol Ligand for Highly Enantioselective Addition of Organozinc Reagents to Aldehydes:  Serendipity Rules
  作者：William A. Nugent

  DOI：10.1021/ol0259488

  日期：2002.6.1

  bis(2-bromoethyl) ether. Subsequent hydrogenation over 5% Rh on alumina in the presence of morpholine unexpectedly stops at the hexahydro derivative 4. Amino alcohol 4 promotes the enantioselective addition of diethylzinc to aldehydes at room temperature in up to 99% enantiomeric excess.

  [反应：见正文]氨基醇4（或其对映体）可通过两个简单步骤制备。用双（2-溴乙基）醚将商业（1R，2S）-2-氨基-1，2-二苯基乙醇二烷基化。随后在吗啉存在下于氧化铝上在Rh上进行超过5％Rh的氢化反应意外地在六氢衍生物4处停止。氨基醇4促进了室温下二乙基锌对醛的对映选择性加成，其对映体过量高达99％。
• Proton-exchanged montmorillonite-mediated reactions of hetero-benzyl acetates: Application to the synthesis of Zafirlukast
  作者：Lei Yang、Xuan Chen、Kaidong Ni、Yuansheng Li、Jianhong Wu、Weilin Chen、Yin Ji、Lili Feng、Fei Li、Dongyin Chen

  DOI：10.1016/j.tetlet.2020.152123

  日期：2020.7

  the mesopores, and serve as an efficient heterogeneous catalyst for the synthesis of heterocycle-containing diarylmethanes via Friedel-Crafts-like alkylation of (hetero)arenes by heterobenzyl acetates under mild reaction conditions without requiring any additives or an inert atmosphere. Using this strategy, the gram-scale synthesis of indole-containing diarylmethane 13 has been accomplished in good yield

  具有出色表面特性的质子交换蒙脱石（H-mont）可以在中孔中提供丰富的酸性位点，并且可以作为一种高效的非均相催化剂，用于通过（杂）芳烃的Friedel-Crafts烷基化合成含杂环的二芳基甲烷杂乙酸乙酸酯在温和的反应条件下不需要任何添加剂或惰性气氛。使用该策略，以高收率完成了含吲哚的二芳基甲烷13的克级合成，从而制备了Zafirlukast。此外，H-mont可用于乙酸杂苄酯5p与多种醇和1,3-二羰基化合物的亲核取代反应。
• ELECTRO-CHEMICAL SENSORS, SENSOR ARRAYS AND CIRCUITS
  申请人：The Johns Hopkins University

  公开号：US20130161599A1

  公开（公告）日：2013-06-27

  An electro-chemical sensor includes a first electrode, a second electrode spaced apart from the first electrode, and a semiconductor channel in electrical contact with the first and second electrodes. The semiconductor channel includes a trapping material. The trapping material reduces an ability of the semiconductor channel to conduct a current of charge carriers by trapping at least some of the charge carriers to localized regions within the semiconductor channel. The semiconductor channel includes at least a portion configured to be exposed to an analyte to be detected, and the trapping material, when exposed to the analyte, interacts with the analyte so as to at least partially restore the ability of the semiconductor channel to conduct the current of charge carriers.

  一种电化学传感器包括第一电极、与第一电极间隔的第二电极和与第一和第二电极电接触的半导体通道。半导体通道包括一个捕获材料，该捕获材料通过将至少一些电荷载体捕获到半导体通道内的局部区域来降低半导体通道导电载流子的能力。半导体通道包括至少一部分被配置为暴露于待检测的分析物，并且当暴露于分析物时，捕获材料与分析物相互作用，以至少部分恢复半导体通道导电载流子的能力。
• Electro-chemical sensors, sensor arrays and circuits
  申请人：The Johns Hopkins University

  公开号：US08772764B2

  公开（公告）日：2014-07-08

  An electro-chemical sensor includes a first electrode, a second electrode spaced apart from the first electrode, and a semiconductor channel in electrical contact with the first and second electrodes. The semiconductor channel includes a trapping material. The trapping material reduces an ability of the semiconductor channel to conduct a current of charge carriers by trapping at least some of the charge carriers to localized regions within the semiconductor channel. The semiconductor channel includes at least a portion configured to be exposed to an analyte to be detected, and the trapping material, when exposed to the analyte, interacts with the analyte so as to at least partially restore the ability of the semiconductor channel to conduct the current of charge carriers.

  一种电化学传感器包括第一电极、距离第一电极间隔的第二电极和与第一和第二电极电接触的半导体通道。半导体通道包括一个捕获材料，该捕获材料通过将至少一些电荷载体困住在半导体通道内的局部区域来降低半导体通道传导电荷载体电流的能力。半导体通道包括至少一个部分被配置为暴露于待检测的分析物，当捕获材料暴露于分析物时，与分析物相互作用，以至少部分恢复半导体通道传导电荷载体电流的能力。
• CARBON NANOTUBE COMPOSITE, SEMICONDUCTOR DEVICE, AND SENSOR USING SAME
  申请人：TORAY INDUSTRIES, INC.

  公开号：US20160155948A1

  公开（公告）日：2016-06-02

  A carbon nanotube composite has an organic substance attached to at least a part of a surface thereof. At least one functional group selected from a hydroxyl group, a carboxy group, an amino group, a mercapto group, a sulfo group, a phosphonic acid group, an organic or inorganic salt thereof, a formyl group, a maleimide group and a succinimide group is contained in at least a part of the carbon nanotube composite.

  一种碳纳米管复合材料，其表面至少有一部分附着有有机物质。该碳纳米管复合材料的至少一部分含有羟基、羧基、氨基、巯基、磺酸基、膦酸基、其有机或无机盐、甲酰基、马来酰亚胺基和琥珀酰亚胺基中的至少一种官能团。