1-Cyclooctyl-3-methylthiourea

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫脲类
• 英文名称: 1-Cyclooctyl-3-methylthiourea
• 化学式: C₁₀H₂₀N₂S
• mdl: MFCD05620760
• 分子量: 200.35
• InChiKey: NBHWEYAWXOJHGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  56.2
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• [EN] RAAV WITH CHEMICALLY MODIFIED CAPSID<br/>[FR] RAAV À CAPSIDE CHIMIQUEMENT MODIFIÉE
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENT (CNRS)

  公开号：WO2017212019A1

  公开（公告）日：2017-12-14

  The invention is directed to the field of gene therapy, i.e. gene delivery into target cells, tissue, organ and organism, and more particularly to gene delivery via viral vectors. The inventors showed that it is possible by chemical coupling to modulate the coupling of a ligand in the surface of the capsid of AAV, for example AAV2 and AAV3b. In particular, the present invention relates to a recombinant Adeno-Associated Virus (rAAV) vector particle having at least one primary amino group contained in the capsid proteins, chemically coupled with at least one ligand L, wherein coupling of said ligand L is implemented through a bond comprising a -CSNH- bond and an optionally substituted aromatic moiety. Particularly, the inventors tested the chemical coupling of mannose ligand on AAV2 for subretinally injection to rats. The present invention further relates to a method for chemically coupling an Adeno-Associated Virus (AAV) vector particle with at least one ligand L and to a Recombinant Adeno-Associated Virus (rAAV) vector particle obtained by said method as well as a pharmaceutical composition comprising it and their corresponding medical use.