4-(fluoren-9-ylidene)-2-hydroxynaphthalen-1-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 4-(fluoren-9-ylidene)-2-hydroxynaphthalen-1-one
• 英文别名: 4-fluoren-9-ylidene-2-hydroxy-4H-naphthalen-1-one；4-Fluoren-9-yliden-2-hydroxy-4H-naphthalin-1-on；4-Fluoren-9-ylidene-2-hydroxynaphthalen-1-one
• 化学式: C₂₃H₁₄O₂
• 分子量: 322.363
• InChiKey: VCUSRMBDIADSGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  25
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(fluoren-9-ylidene)-2-hydroxynaphthalen-1-one 、 溶剂黄146 、 alkaline earth salt of/the/ methylsulfuric acid 生成 4-fluoren-9-yl-naphthalene-1,2-diol
  参考文献：
  名称：

  Sachs; Oeholm, Chemische Berichte, 1914, vol. 47, p. 959

  摘要：

  DOI：
• 作为产物：
  描述：

  芴 、 sodium 1,2-naphthoquinone-4-sulfonate 在 potassium tert-butylate 作用下， 以 PEG 300 为溶剂， 以68%的产率得到4-(fluoren-9-ylidene)-2-hydroxynaphthalen-1-one
  参考文献：
  名称：

  Polyethylene Glycol (PEG 300) and Water–Ethanol as Benign Solvent Systems for the Synthesis of a Novel Series of 2-Hydroxynaphthalen-1(4H)-Ones

  摘要：

  An improved, clean, simple, and efficient method for the synthesis of new series of 2-hydroxy-4-methylenenaphthalen-1(4H)-one is described. This new process involves a domino Michael addition of various methylene acid compounds with the sodium salt of 1,2-naphthoquinone-4-sulfonate either in basic (tBuOK) polyethylene glycol (PEG300) at room temperature or in a basic (NaOH) water-ethanol medium at 40 degrees C by a crushing in a mortar or a traditional heating.

  DOI：

  10.1080/00397911003797916

文献信息

• Polyethylene Glycol (PEG 300) and Water–Ethanol as Benign Solvent Systems for the Synthesis of a Novel Series of 2-Hydroxynaphthalen-1(4<i>H</i>)-Ones
  作者：D. Villemin、M. Benabdallah、N. Choukchou-Braham、B. Mostefa-Kara

  DOI：10.1080/00397911003797916

  日期：2010.9.20

  An improved, clean, simple, and efficient method for the synthesis of new series of 2-hydroxy-4-methylenenaphthalen-1(4H)-one is described. This new process involves a domino Michael addition of various methylene acid compounds with the sodium salt of 1,2-naphthoquinone-4-sulfonate either in basic (tBuOK) polyethylene glycol (PEG300) at room temperature or in a basic (NaOH) water-ethanol medium at 40 degrees C by a crushing in a mortar or a traditional heating.
• Sachs; Oeholm, Chemische Berichte, 1914, vol. 47, p. 959
  作者：Sachs、Oeholm

  DOI：——

  日期：——