3-N-benzyl-2,2,5,5-tetramethyl-1,3-oxazolidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-N-benzyl-2,2,5,5-tetramethyl-1,3-oxazolidine
• 英文别名: 3-benzyl-2,2,5,5-tetramethyl-1,3-oxazolidine
• 化学式: C₁₄H₂₁NO
• 分子量: 219.327
• InChiKey: CWODLJALJOQTPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甲基环氧丙烷 、 N-(isopropylidene)benzylamine 在 samarium diiodide 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 以93%的产率得到3-N-benzyl-2,2,5,5-tetramethyl-1,3-oxazolidine
  参考文献：
  名称：

  Synthesis of 1,3-oxazolidines from imines and epoxides catalyzed by samarium compounds

  摘要：

  A new method for the synthesis of 1,3-oxazolidine derivatives has been developed. Thus, a variety of 1,3-oxazolidines was prepared by the reaction of imines with epoxides in the presence of a catalytic amount of a samarium compound such as SmI2, SmI3, or Cp*Sm-2(thf)(2). (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00374-9

文献信息

• Process for producing 1,3-oxazolidine derivatives
  申请人：Daicel Chemical Industries, Ltd.

  公开号：EP1026161B1

  公开（公告）日：2004-07-21
• US6271387B1
  申请人：——

  公开号：US6271387B1

  公开（公告）日：2001-08-07
• Synthesis of 1,3-oxazolidines from imines and epoxides catalyzed by samarium compounds
  作者：Takayuki Nishitani、Hiroyuki Shiraishi、Satoshi Sakaguchi、Yasutaka Ishii

  DOI：10.1016/s0040-4039(00)00374-9

  日期：2000.4

  A new method for the synthesis of 1,3-oxazolidine derivatives has been developed. Thus, a variety of 1,3-oxazolidines was prepared by the reaction of imines with epoxides in the presence of a catalytic amount of a samarium compound such as SmI2, SmI3, or Cp*Sm-2(thf)(2). (C) 2000 Elsevier Science Ltd. All rights reserved.