2,4-dimethyl-8-hexadecyl-5,6,7,8-tetrahydro[1,8]naphthyridin-3-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2,4-dimethyl-8-hexadecyl-5,6,7,8-tetrahydro[1,8]naphthyridin-3-ol
• 英文别名: 8-hexadecyl-2,4-dimethyl-6,7-dihydro-5H-1,8-naphthyridin-3-ol
• 化学式: C₂₆H₄₆N₂O
• 分子量: 402.664
• InChiKey: QLCNMFKGTYZRFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  29
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  36.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  十六醛 在 正丁基锂 、 三乙酰氧基硼氢化钠 、 溶剂黄146 作用下， 以 四氢呋喃 、 正己烷 、 1,2-二氯乙烷 为溶剂， 反应 7.0h， 生成 2,4-dimethyl-8-hexadecyl-5,6,7,8-tetrahydro[1,8]naphthyridin-3-ol
  参考文献：
  名称：

  Lipid-Soluble 3-Pyridinol Antioxidants Spare α-Tocopherol and Do Not Efficiently Mediate Peroxidation of Cholesterol Esters in Human Low-Density Lipoprotein

  摘要：

  Because alpha-tocopherol (alpha-TOH) mediates the peroxidation of cholesterol-esterified lipids in human low-density lipoprotein (LDL) in vitro and has displayed disappointing results against the onset and development of atherosclerosis, it may not be appropriate for use as a therapeutic in the prevention and/or treatment of the disease. Herein are described the experimental results demonstrating that 3-pyridinols spare alpha-TOH, do not efficiently mediate lipid peroxidation, and protect lipoprotein tryptophan residues in human LDL.

  DOI：

  10.1021/jm0507173

文献信息

• Lipid-Soluble 3-Pyridinol Antioxidants Spare α-Tocopherol and Do Not Efficiently Mediate Peroxidation of Cholesterol Esters in Human Low-Density Lipoprotein
  作者：Hye-Young Kim、Derek A. Pratt、Jennifer R. Seal、Maikel Wijtmans、Ned A. Porter

  DOI：10.1021/jm0507173

  日期：2005.11.1

  Because alpha-tocopherol (alpha-TOH) mediates the peroxidation of cholesterol-esterified lipids in human low-density lipoprotein (LDL) in vitro and has displayed disappointing results against the onset and development of atherosclerosis, it may not be appropriate for use as a therapeutic in the prevention and/or treatment of the disease. Herein are described the experimental results demonstrating that 3-pyridinols spare alpha-TOH, do not efficiently mediate lipid peroxidation, and protect lipoprotein tryptophan residues in human LDL.