3-acetamido-2,4-dihydroxybenzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-acetamido-2,4-dihydroxybenzoic acid
• 英文别名: 3-Acetamido-2,4-dihydroxybenzoic acid
• 化学式: C₉H₉NO₅
• 分子量: 211.174
• InChiKey: ORJDRSLFEGDSIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,6-二甲氧基苯硼酸 在 三溴化硼 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 sodium hydroxide 、 hydroxylamine-O-sulfonic acid 作用下， 以 二氯甲烷 、 水 、 乙腈 为溶剂， 100.0 ℃ 、2.0 MPa 条件下， 反应 25.0h， 生成 3-acetamido-2,4-dihydroxybenzoic acid
  参考文献：
  名称：

  在环境条件下由有机碱介导的Kolbe–Schmitt型反应†

  摘要：

  间苯二酚有机碱的组合使用在环境条件下实现了Kolbe-Schmitt型反应。当将间苯二酚（3-羟基苯酚衍生物）在二氧化碳气氛下用DBU处理时，亲核加成反应继续进行，从而以高收率得到了相应的水杨酸衍生物。

  DOI：

  10.1039/c9cc04550c

文献信息

• Metal-containing platensimycin analogues
  申请人：Ruhr-Universität Bochum

  公开号：EP2226329A1

  公开（公告）日：2010-09-08

  The present invention relates to metal-containing platensimycin analogues as well as pharmaceutical compositions comprising such compounds and methods for preparing such compounds. The present invention is further directed to the use of these compounds, alone or in combination with other therapeutic agents, for the alleviation, prevention and/or treatment of diseases and disorders, such as obesity, cancer, diabetes, fungal infections, bacterial infections, malarial infections and other apicomplexan protozoal diseases.

  本发明涉及含金属的普拉霉素类似物以及包含此类化合物的药物组合物和制备此类化合物的方法。本发明进一步涉及这些化合物单独或与其他治疗剂联合用于缓解、预防和/或治疗疾病和紊乱，如肥胖症、癌症、糖尿病、真菌感染、细菌感染、疟疾感染和其他 apicomplexan 原生动物疾病。
• COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED NAPHTHALIMIDES SUCH AS AMONAFIDE FOR THE TREATMENT OF IMMUNOLOGICAL, METABOLIC, INFECTIOUS, AND BENIGN OR NEOPLASTIC HYPERPROLIFERATIVE DISEASE CONDITIONS
  申请人：BROWN Dennis M.

  公开号：US20160067241A1

  公开（公告）日：2016-03-10

  The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to naphthalimides such as amonafide or analogs, derivatives, or prodrugs thereof.
• [EN] COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED NAPHTHALIMIDES SUCH AS AMONAFIDE FOR THE TREATMENT OF IMMUNOLOGICAL, METABOLIC, INFECTIOUS, AND BENIGN OR NEOPLASTIC HYPERPROLIFERATIVE DISEASE CONDITIONS<br/>[FR] COMPOSITIONS ET PROCÉDÉS PERMETTANT D'AMÉLIORER LE BÉNÉFICE THÉRAPEUTIQUE DES COMPOSÉS CHIMIQUES ADMINISTRÉS DE MANIÈRE SUBOPTIMALE COMPRENANT DES NAPHTALIMIDES SUBSTITUÉS TELS QUE L'AMONAFIDE POUR LE TRAITEMENT DES MALADIES IMMUNOLOGIQUES, MÉTABOLIQUES, INFECTIEUSES ET INFECTIEUSES OU HYPERPROLIFÉRATIVES ET NÉOPLASTIQUES.
  申请人：BROWN DENNIS M

  公开号：WO2014179528A2

  公开（公告）日：2014-11-06

  The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to naphthalimides such as amonafide or analogs, derivatives, or prodrugs thereof.
• Kolbe–Schmitt type reaction under ambient conditions mediated by an organic base
  作者：Yuta Sadamitsu、Akira Okumura、Kodai Saito、Tohru Yamada

  DOI：10.1039/c9cc04550c

  日期：——

  The combined use of an organic base for resorcinols realized a Kolbe–Schmitt type reaction under ambient conditions. When resorcinols (3-hydroxyphenol derivatives) were treated with DBU under a carbon dioxide atmosphere, nucleophilic addition to carbon dioxide proceeded to afford the corresponding salicylic acid derivatives in high yields.

  间苯二酚有机碱的组合使用在环境条件下实现了Kolbe-Schmitt型反应。当将间苯二酚（3-羟基苯酚衍生物）在二氧化碳气氛下用DBU处理时，亲核加成反应继续进行，从而以高收率得到了相应的水杨酸衍生物。