4-methylphenyl cyclohexyl(methyl)phosphinate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methylphenyl cyclohexyl(methyl)phosphinate
• 英文别名: 1-[Cyclohexyl(methyl)phosphoryl]oxy-4-methylbenzene
• 化学式: C₁₄H₂₁O₂P
• 分子量: 252.293
• InChiKey: OGAUEFMDYYMZGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对甲苯甲醚 、 环己二氯膦 在 三氯化铝 、 水 作用下， 以 二氯甲烷 为溶剂， 以60%的产率得到4-methylphenyl cyclohexyl(methyl)phosphinate
  参考文献：
  名称：

  One-pot synthesis of unsymmetrical aryl methylphosphinates by insertion of dichlorophosphines into the OMe bond of anisoles

  摘要：

  This letter describes a new one-pot method for the synthesis of unsymmetrical aryl methylphoshinates by insertion of phosphorus moiety into the O (.) Me bond of anisoles. These products are very difficult to obtain with other reported methods requiring several steps. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01197-2

文献信息

• One-pot synthesis of unsymmetrical aryl methylphosphinates by insertion of dichlorophosphines into the OMe bond of anisoles
  作者：Graziano Baccolini、Carla Boga

  DOI：10.1016/s0040-4039(01)01197-2

  日期：2001.8

  This letter describes a new one-pot method for the synthesis of unsymmetrical aryl methylphoshinates by insertion of phosphorus moiety into the O (.) Me bond of anisoles. These products are very difficult to obtain with other reported methods requiring several steps. (C) 2001 Elsevier Science Ltd. All rights reserved.