(R)-4-di(4-methoxyphenyl)phosphinyl-13-(4-phenyloxazolin-2-yl)[2.2]paracyclophane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-4-di(4-methoxyphenyl)phosphinyl-13-(4-phenyloxazolin-2-yl)[2.2]paracyclophane
• 英文别名: bis(4-methoxyphenyl)-[12-[(4R)-4-phenyl-4,5-dihydro-1,3-oxazol-2-yl]-5-tricyclo[8.2.2.24,7]hexadeca-1(12),4,6,10,13,15-hexaenyl]phosphane
• 化学式: C₃₉H₃₆NO₃P
• 分子量: 597.693
• InChiKey: CLHSWUASQRHDLG-QNGWXLTQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  44
• 可旋转键数：
  7
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  40
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  氯二(4-甲氧苯基)膦 、 (R,4Sp,13Rp)-4-bromo-13-(4-phenyloxazolin-2-yl)[2.2]paracyclophane 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 3.0h， 以46%的产率得到(R)-4-di(4-methoxyphenyl)phosphinyl-13-(4-phenyloxazolin-2-yl)[2.2]paracyclophane
  参考文献：
  名称：

  Novel planar chiral P,N-[2.2]paracyclophane ligands: synthesis and application in palladium-catalyzed allylic alkylation

  摘要：

  A series of planar chiral P,N-[2.2]paracyclophane ligands were synthesized and applied in enantio selective palladium-catalyzed allylic alkylation, in which the central chirality of [2.2]paracyclophane is the dominant stereocontrol element. The effect of the substituents attached to the phosphorus atom of these ligands on the yield and stereoselectivity of the reaction was also investigated. (C) 2003 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(02)00790-5

文献信息

• Novel planar chiral P,N-[2.2]paracyclophane ligands: synthesis and application in palladium-catalyzed allylic alkylation
  作者：Xun-Wei Wu、Ke Yuan、Wei Sun、Ming-Jie Zhang、Xue-Long Hou

  DOI：10.1016/s0957-4166(02)00790-5

  日期：2003.1

  A series of planar chiral P,N-[2.2]paracyclophane ligands were synthesized and applied in enantio selective palladium-catalyzed allylic alkylation, in which the central chirality of [2.2]paracyclophane is the dominant stereocontrol element. The effect of the substituents attached to the phosphorus atom of these ligands on the yield and stereoselectivity of the reaction was also investigated. (C) 2003 Published by Elsevier Science Ltd.