biphenyl-alcohol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: biphenyl-alcohol
• 英文别名: 1-hydroxybiphenyl；1-Phenylphenol；1-phenylcyclohexa-2,4-dien-1-ol
• 化学式: C₁₂H₁₂O
• 分子量: 172.227
• InChiKey: GNBRZRRANUHHGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  biphenyl-alcohol 、 (S)-4-[(Chloro)methylphosphinyl]-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]butanoic acid, methyl ester 、 phosphinochloridate 、 三乙胺 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 以67%的产率得到(3S)-4-[[[4'-Fluoro-3,3',5-trimethyl[1,1'-biphenyl]-2-yl]methoxy]methylphosphinyl]-3-t-butyldiphenylsilyloxybutanoic acid, methyl ester
  参考文献：
  名称：

  Phosphorus-containing HMG-COA reductase inhibitors

  摘要：

  提供了作为胆固醇生物合成抑制剂和低胆固醇药物的有用化合物，其结构为##STR1##包括其盐，其中R为OH、较低的烷氧基或较低的烷基；R.sup.x为H或烷基；X为--O--或--NH--；n为1或2，Z为疏水锚，例如##STR2##其中虚线表示可选的双键。还提供了用于制备上述化合物的新中间体，含有此类化合物的药物组合物以及使用这些化合物抑制胆固醇生物合成的方法。

  公开号：

  US04904646A1

文献信息

• Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands
  申请人：BIOPROJET

  公开号：EP1717234A1

  公开（公告）日：2006-11-02

  The present patent application concerns compounds of formula (I), with R1 and R2 taken together with the nitrogen atom to which they are attached, form a mono or bicyclic saturated nitrogen-containing ring; their preparation and their use as a H3 receptor ligand for treating e.g. CNS disorders like Alzheimer's disease.

  本专利申请涉及公式（I）的化合物，其中R1和R2与它们所连接的氮原子一起形成一个单环或双环饱和氮含环；它们的制备以及它们作为H3受体配体用于治疗例如阿尔茨海默病等中枢神经系统疾病。
• [EN] BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS<br/>[FR] BIPHENYL SULFONAMIDES UTILISES COMME DOUBLES ANTAGONISTES DES RECEPTEURS DE L'ANGIOTENSINE ET DE L'ENDOTHELINE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2001044239A2

  公开（公告）日：2001-06-21

  Novel biphenyl sulfonamide compounds which are combined angiotensin and endothelin receptor antagonists are claimed along with methods of using such compounds in the treatment of conditions such as hypertension and other diseases, as well as pharmaceutical compositions containing such compounds.

  本专利申请涉及一种新型的联合血管紧张素和内皮素受体拮抗剂的新型二苯基磺酰胺化合物，以及使用这些化合物治疗高血压和其他疾病的方法，同时还包括含有这些化合物的制药组合物。
• NOVEL HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS
  申请人：Bertrand Isabelle

  公开号：US20090111808A1

  公开（公告）日：2009-04-30

  The present patent application concerns compounds of formula (I) with R1 and R2 taken together with the nitrogen atom to which they are attached, form a mono or bicyclic saturated nitrogen-containing ring; their preparation and their use as a H3 receptor ligand for treating e.g. CNS disorders like Alzheimer's disease.

  本专利申请涉及式(I)的化合物，其中R1和R2与它们所连接的氮原子结合形成单环或双环饱和含氮环; 它们的制备及其用作H3受体配体，用于治疗例如阿尔茨海默病等中枢神经系统疾病。
• Histamine H3-receptor ligands and their therapeutic applications
  申请人：Bioprojet

  公开号：US08076329B2

  公开（公告）日：2011-12-13

  The present patent application concerns compounds of formula (I) with R1 and R2 taken together with the nitrogen atom to which they are attached, form a mono or bicyclic saturated nitrogen-containing ring; their preparation and their use as a H3 receptor ligand for treating e.g. CNS disorders like Alzheimer's disease.

  本专利申请涉及公式（I）化合物，其中R1和R2与它们附着的氮原子一起形成单环或双环饱和含氮环；它们的制备以及它们作为H3受体配体用于治疗例如阿尔茨海默病等中枢神经系统疾病。
• Azetidine Derivatives
  申请人：Vernalis (R&D) Ltd.

  公开号：US20150183769A1

  公开（公告）日：2015-07-02

  Compounds of formula (I) are inhibitors of fatty acid amide hydrolase, (FAAH), and which are useful in the treatment of diseases or medical conditions which benefit from inhibition of FAAH activity, such as anxiety, depression pain, inflammation, and eating, sleep, neurodegenerative and movement disorders: Wherein Ar 1 is optionally substituted phenyl or optionally substituted monocyclic heteroaryl having 5 or 6 ring atoms; Ar 2 is optionally substituted phenyl, optionally substituted monocyclic heteroaryl having 5 or 6 ring atoms or optionally substituted fused bicyclic heteroaryl having 5 or 6 ring atoms in each fused ring; and Ar 3 is a divalent radical selected from the group consisting of optionally substituted phenylene and optionally substituted monocyclic heteroarylene radicals having 5 or 6 ring atoms.

  化合物(I)的式子是FAAH（脂肪酸酰胺水解酶）的抑制剂，对于需要抑制FAAH活性的疾病或医疗状况有用，例如焦虑、抑郁、疼痛、炎症、饮食、睡眠、神经退行性和运动障碍。其中，Ar1是可选取取代苯基或可选取取代的5或6环原子单环杂芳基；Ar2是可选取取代苯基、可选取取代的5或6环原子单环杂芳基或每个融合环中都有5或6环原子的可选取取代的融合双环杂芳基；而Ar3是从可选取取代的苯基和可选取取代的5或6环原子单环杂芳基基团中选择的二价基团。