1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphoethanolamine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphoethanolamine
• 英文别名: 1,2-(tricosa-10’,12’-diynoyl)-sn-glycero-3-phosphoethanolamine；DTPE；2-azaniumylethyl [(2R)-2,3-di(tricosa-10,12-diynoyloxy)propyl] phosphate
• 化学式: C₅₁H₈₆NO₈P
• 分子量: 872.219
• InChiKey: ZBLCBXGAYXHPIY-ANFMRNGASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.1
• 重原子数：
  61
• 可旋转键数：
  45
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  134
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphoethanolamine 、 2,5-dioxopyrrolidin-1-yl 5-azidopentanoate 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  Folic acid-tethered poly(N-isopropylacrylamide)–phospholipid hybrid nanocarriers for targeted drug delivery

  摘要：

  叶酸-缀合聚（异丙基丙烯酰胺）-磷脂纳米载体在生理条件下表现出肿瘤靶向性和温度响应性阿霉素释放行为。

  DOI：

  10.1039/c5tb01063b

文献信息

• Grid coatings for capture of proteins and other compounds
  申请人：Purdue Research Foundation

  公开号：US10989681B2

  公开（公告）日：2021-04-27

  Grids comprising a coating modified with one or more capture agents and a deactivating agent are disclosed. Methods of using such grids in connection with suitable microscopy techniques, such as for determining the structure of target compounds including proteins, are also disclosed.

  揭示了包括涂层经过改性的一种或多种捕获剂和一种失活剂的网格。还公开了使用这种网格结合适当的显微镜技术的方法，例如用于确定目标化合物（包括蛋白质）的结构。
• PROCESS FOR THE PREPARATION OF AN OBJECT SUPPORTING A LIPID BILAYER
  申请人：UNIVERSITEIT TWENTE

  公开号：US20160096920A1

  公开（公告）日：2016-04-07

  A process for the preparation of an object, supporting a lipid bilayer, for use in tissue engineering including the steps of providing an object having a surface, treating the surface of the object with a plasma containing active oxygen to provide the surface of the object with reactive groups A, to provide the surface of the object with reactive groups A, covalently attaching a sterol group to the reactive groups A and contacting the object activated with sterol groups with a lipid solution to form a lipid bilayer.

  一种用于组织工程的支持脂质双层的物体制备方法，包括以下步骤：提供具有表面的物体，用含有活性氧的等离子体处理物体表面，以提供物体表面的反应性基团A，将甾醇基团共价键合到反应性基团A上，并将活化了甾醇基团的物体与脂质溶液接触以形成脂质双层。
• Process for the preparation of an object supporting a lipid bilayer
  申请人：UNIVERSITEIT TWENTE

  公开号：EP2803372A1

  公开（公告）日：2014-11-19

  The invention is directed to a process for the preparation of an object supporting a lipid bilayer comprising the steps of - Providing an object, - Treating the object with active oxygen to provide the surface of the object with reactive groups A, - Covalently attaching a sterol group to the reactive groups A and - Contacting the object activated with sterol groups with a lipid solution to form a lipid bilayer.

  本发明涉及一种制备支撑脂质双分子层的物体的工艺，包括以下步骤 - 提供一个物体、 - 用活性氧处理物体，使物体表面具有活性基团 A、 - 将固醇基团共价连接到反应基团 A 上，以及 - 将被固醇基团激活的物体与脂质溶液接触，形成脂质双分子层。
• AMPHIPHILIC MOLECULES LAYERS
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS-

  公开号：EP3156046A1

  公开（公告）日：2017-04-19

  The disclosure relates to a layer comprising at least one hydrophilic part and at least one hydrophobic part, the layer comprising self-assembled amphiphilic molecules polymerized with each other on both the hydrophilic part and the hydrophobic part of the layer; a detecting device comprising a substrate and the above-mentioned layer; and a liposome, a micelle, transport system for a substance and a biomimetic system comprising the above-mentioned layer. The disclosure also relates to a process for producing a layer, the process comprising: providing amphiphilic molecules; allowing sufficient time for the amphiphilic molecules to self-assemble and form at least one hydrophilic part and at least one hydrophobic part of the layer; polymerizing the self-assembled amphiphilic molecules with each other on both the hydrophilic part and the hydrophobic part of the layer.

  本发明涉及一种由至少一个亲水部分和至少一个疏水部分组成的层，该层包括亲水部分和疏水部分上相互聚合的自组装两亲分子；一种由基底和上述层组成的检测装置；以及一种由上述层组成的脂质体、胶束、物质运输系统和仿生物系统。本公开还涉及一种生产层的工艺，该工艺包括：提供两亲分子；给两亲分子足够的时间自组装并形成层的至少一个亲水部分和至少一个疏水部分；在层的亲水部分和疏水部分上使自组装的两亲分子相互聚合。
• UNIVERSAL METHOD FOR THE PREPARATION OF LIPID-BASED COATINGS
  申请人：LipoCoat B.V.

  公开号：EP3530265A1

  公开（公告）日：2019-08-28

  The invention relates to a process for making lipid-coated substrates comprising the steps of a. Providing a lipid solution (A) of phospholipids in a water miscible organic solvent at a phospholipid concentration between 25 and 450 mg/ml; b. Provide an aqueous solution (B) having pH between 4 and 8; c. Agitate the aqueous solution (B) and dispense the lipid solution (A) into the aqueous solution (B) to prepare an aqueous dispersion comprising lipid vesicles (C) having a number average size between 80 and 120 nm (measured according to dynamic light scattering) at a phospholipid concentration between 0.05 mg/ml and 2 mg/ml; and d. Applying the aqueous dispersion (C) to a substrate and formation of a lipid-based coating; e. Wherein aqueous dispersion (C) contains at least 95 wt% water. The invention further relates to medical devices comprising a lipid-based coating, for example contact lenses and catheters.

  本发明涉及一种制作脂质涂层基底的工艺，包括以下步骤 a.在水可混溶的有机溶剂中提供磷脂溶液（A），磷脂浓度在 25 至 450 毫克/毫升之间； b.提供 pH 值介于 4 和 8 之间的水溶液 (B)； c.搅拌水溶液（B）并将脂质溶液（A）分配到水溶液（B）中，以制备包含脂质囊泡 （C）的水分散液，脂质囊泡的平均粒径在 80 纳米到 120 纳米之间（根据动态光散射法测定），磷脂浓度在 0.05 毫克/毫升到 2 毫克/毫升之间；以及 d.将水分散液 (C) 涂在基底上，形成脂基涂层； e.其中水性分散液（C）含有至少 95 wt%的水。 本发明还涉及包含脂基涂层的医疗设备，例如隐形眼镜和导管。