2-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-3,5-dimethoxy-phenyl}-2,2-dimethoxy-ethanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-3,5-dimethoxy-phenyl}-2,2-dimethoxy-ethanol
• 英文别名: 2-[4-[2-[Tert-butyl(dimethyl)silyl]oxyethoxy]-3,5-dimethoxyphenyl]-2,2-dimethoxyethanol；2-[4-[2-[tert-butyl(dimethyl)silyl]oxyethoxy]-3,5-dimethoxyphenyl]-2,2-dimethoxyethanol
• 化学式: C₂₀H₃₆O₇Si
• 分子量: 416.587
• InChiKey: GPCWPUDQLAADDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.54
• 重原子数：
  28
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  75.6
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-3,5-dimethoxy-phenyl}-2,2-dimethoxy-ethanol 在 吡啶 、 四丁基氟化铵 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 0.25h， 生成 carbonic acid 2-[4-(2-hydroxy-ethoxy)-3,5-dimethoxy-phenyl]-2,2-dimethoxy-ethyl ester 2-(2-nitro-phenyl)-propyl ester
  参考文献：
  名称：

  Spatial Photorelease of Oligonucleotides, Using a Safety-Catch Photolabile Linker

  摘要：

  We report the development of a safety-catch photolabile linker that allows the light-directed synthesis and spatially selective photorelease of oligonucleotides from microarrays. The linker remains stable to light during DNA synthesis, and is activated for photorelease after acidic hydrolysis. We demonstrate that the photoreleased oligonucleotides can be amplified by PCR to produce double stranded DNA. The advantages offered by this linker could aid the development of an automated gene synthesis platform.

  DOI：

  10.1021/ol060644x
• 作为产物：
  描述：

  叔丁基二甲基羟乙氧基硅烷 在 氢氧化钾 、 碘苯二乙酸 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 生成 2-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-3,5-dimethoxy-phenyl}-2,2-dimethoxy-ethanol
  参考文献：
  名称：

  Spatial Photorelease of Oligonucleotides, Using a Safety-Catch Photolabile Linker

  摘要：

  We report the development of a safety-catch photolabile linker that allows the light-directed synthesis and spatially selective photorelease of oligonucleotides from microarrays. The linker remains stable to light during DNA synthesis, and is activated for photorelease after acidic hydrolysis. We demonstrate that the photoreleased oligonucleotides can be amplified by PCR to produce double stranded DNA. The advantages offered by this linker could aid the development of an automated gene synthesis platform.

  DOI：

  10.1021/ol060644x

文献信息

• Spatial Photorelease of Oligonucleotides, Using a Safety-Catch Photolabile Linker
  作者：Shane T. Flickinger、Madhusudan Patel、Brock F. Binkowski、Aaron M. Lowe、Mo-Huang Li、Changhan Kim、Franco Cerrina、Peter J. Belshaw

  DOI：10.1021/ol060644x

  日期：2006.5.1

  We report the development of a safety-catch photolabile linker that allows the light-directed synthesis and spatially selective photorelease of oligonucleotides from microarrays. The linker remains stable to light during DNA synthesis, and is activated for photorelease after acidic hydrolysis. We demonstrate that the photoreleased oligonucleotides can be amplified by PCR to produce double stranded DNA. The advantages offered by this linker could aid the development of an automated gene synthesis platform.