syn-3-hydroxy-2-methyl-3-phenylpropanylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: syn-3-hydroxy-2-methyl-3-phenylpropanylamine
• 英文别名: erythro-2-Methyl-1-phenyl-3-amino-1-propanol；(1R,2S)-3-amino-2-methyl-1-phenylpropan-1-ol
• 化学式: C₁₀H₁₅NO
• 分子量: 165.235
• InChiKey: RWQFRJRWVSFINF-WCBMZHEXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  α-Aminomethyl-propiophenon-hydrochlorid 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 生成 syn-3-hydroxy-2-methyl-3-phenylpropanylamine
  参考文献：
  名称：

  Koga,K.; Yamada,S.-I., Chemical and pharmaceutical bulletin, 1972, vol. 20, # 3, p. 526 - 538

  摘要：

  DOI：

文献信息

• Stereoselective Complete Reduction of α-Alkyl-β-ketonitriles toanti γ-Amino Alcohols
  作者：Antonio De Nino、Renato Dalpozzo、Giovanna Cupone、Loredana Maiuolo、Antonio Procopio、Antonio Tagarelli、Giuseppe Bartoli

  DOI：10.1002/1099-0690(200209)2002:17<2924::aid-ejoc2924>3.0.co;2-5

  日期：2002.9

  The one-pot reduction of alpha-alkyl-beta-ketonitriles to anti gamma-amino alcohols can be efficiently performed by borane/dimethyl sulfide complex in the presence of cerium chloride as Lewis acid. Selectivities are slightly worse than monoreduction but this drawback is overcome by much better yields. (C) Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
• Boiko,I.P. et al., Journal of Organic Chemistry USSR (English Translation), 1976, vol. 12, # 1, p. 76 - 84
  作者：Boiko,I.P. et al.

  DOI：——

  日期：——
• TAMPER RESISTANT FORMULATION OF EPHEDRINE AND ITS DERIVATIVES
  申请人：GRÜNENTHAL GMBH

  公开号：US20180042868A1

  公开（公告）日：2018-02-15

  A pharmaceutical dosage form having a breaking strength of at least 300 N and comprising an ephedrine component selected from the group consisting of ephedrine, pseudoephedrine and the physiologically acceptable salts thereof, wherein the weight content of the ephedrine component is within the range of from 0.1 to 60 wt.-%, relative to the total weight of the pharmaceutical dosage form.
• Koga,K.; Yamada,S.-I., Chemical and pharmaceutical bulletin, 1972, vol. 20, # 3, p. 526 - 538
  作者：Koga,K.、Yamada,S.-I.

  DOI：——

  日期：——