N,N-diethylterephthalamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-diethylterephthalamide
• 英文别名: N¹,N¹-diethylterephthalamide；4-N,4-N-diethylbenzene-1,4-dicarboxamide
• 化学式: C₁₂H₁₆N₂O₂
• mdl: MFCD17641842
• 分子量: 220.271
• InChiKey: XDVBMAYPGCABDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  63.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-cyano-N,N-diethylbenzamide 在 双氧水 、 potassium carbonate 作用下， 以 水 、 二甲基亚砜 为溶剂， 以67%的产率得到N,N-diethylterephthalamide
  参考文献：
  名称：

  通过烷基硼酸与伯酰胺的铜催化交叉偶联选择性形成仲酰胺

  摘要：

  首次展示了伯酰胺和烷基硼酸交叉偶联的通用催化程序。该反应成功的关键是确定了弱碱（NaOSiMe 3）和氧化剂（二叔丁基过氧化物）以促进铜催化反应的高产率。这种转化为酰胺的单烷基化提供了一种简便、高产的方法。

  DOI：

  10.1021/ol401004r

文献信息

• PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING
  申请人：GUNZNER Janet L.

  公开号：US20110092461A1

  公开（公告）日：2011-04-21

  The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R 1 , R 2 , R 3 , R 4 , m and n are as described herein.

  本发明提供了新型的刺猬信号抑制剂，可用作治疗恶性肿瘤的治疗剂，其中化合物具有一般式I：其中A、X、Y、R1、R2、R3、R4、m和n如本文所述。
• PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE
  申请人：Aicher Babette

  公开号：US20100234377A1

  公开（公告）日：2010-09-16

  The present invention relates to compounds of general formula (I): wherein A, Y, X, n and B are as defined herein; and their use in the treatment and prevention of metabolic disorders, inflammatory conditions, allergic conditions, fever, pain including allodynia and nociception, eating disorders, cachexia, brain injuries, cancer of the genitals, sleep apnea, cardiovascular disease, flush effect associated with nicotinic acid and related compounds or for the promotion of wound healing. Certain compounds of general formula (I) are new and the invention also relates to these compounds and to their use in medicine.

  本发明涉及一般式（I）的化合物：其中A、Y、X、n和B如此定义；以及它们在治疗和预防代谢紊乱、炎症病症、过敏症、发热、疼痛（包括触觉过敏和痛觉敏感）、进食障碍、消瘦症、脑损伤、生殖器癌症、睡眠呼吸暂停、心血管疾病、烟酸及相关化合物引起的潮红反应或促进伤口愈合方面的用途。某些一般式（I）的化合物是新的，本发明还涉及这些化合物及其在医学上的应用。
• Direct magnesiation of organic materials
  申请人：ARCH DEVELOPMENT CORPORATION

  公开号：EP0418013A2

  公开（公告）日：1991-03-20

  A method for magnesiating a compound substituted with one or more activating groups beta (ortho) to a carbon atom having a hydrogen substituent to be deprotonated. The compound is either a saturated cyclic compound in which the carbon-carbon bonds are strained greater than the carbon-carbon bonds of cyclobutane, or an unsaturated compound in which the carbon atom to be deprotonated is located no more than one position away from a pi-bonded carbon atom. The method contacts the substituted compound with a reactant having the formula: wherein W is: and R₁, R₂, R₃ and R₄ independently include hydrogen, alkyl, aryl, alkylaryl, and heteroaryl, or R and R₂ and/or R₃ and R₄ together form a cyclic residue. Compounds substituted with one or more magnesium-­containing groups and one or more activating groups are also disclosed. The activated compounds are either saturated cyclic compounds having carbon-carbon bonds that are strained greater than the carbon-carbon bonds of cyclobutane, or unsaturated compounds. The one or more magnesium-containing groups have the structure: with R₁ and R₂ independently including hydrogen, alkyl, aryl, alkylaryl, and heteroaryl, or R₁ and R₂ together forming a cyclic residue. A method by which such compounds are reacted with electrophilic reagents replacing the magnesium containing groups with substituent groups is also disclosed.

  一种镁化化合物的方法，该化合物被一个或多个活化基团β（正交）取代，该基团与具有氢取代基的碳原子相连，该碳原子将被去质子化。该化合物可以是饱和环状化合物，其中碳-碳键的张力大于环丁烷的碳-碳键；也可以是不饱和化合物，其中需要去质子化的碳原子与π键碳原子的距离不超过一个位置。该方法将取代的化合物与具有以下式子的反应物接触： 其中 W 是 和 R₁、R₂、R₃ 和 R₄ 独立地包括氢、烷基、芳基、烷芳基和杂芳基，或 R 和 R₂ 和/或 R₃ 和 R₄ 共同形成环状残基。此外，还公开了被一个或多个含镁基团和一个或多个活化基团取代的化合物。活化化合物可以是饱和环状化合物，其碳-碳键的张力大于环丁烷的碳-碳键，也可以是不饱和化合物。一个或多个含镁基团的结构如下 R₁ 和 R₂ 独立地包括氢、烷基、芳基、烷芳基和杂芳基，或 R₁ 和 R₂ 共同形成环状残基。此外，还公开了一种方法，通过该方法，此类化合物可与亲电试剂反应，用取代基取代含镁基团。
• Complexed hydroquinones
  申请人：POLAROID CORPORATION

  公开号：EP0523470A2

  公开（公告）日：1993-01-20

  Hydroquinones form stable hydrogen-bonded complexes with N,N,N',N'-tetrasubstituted diamides of aromatic dicarboxylic acids in which two carboxyl groups are arranged para to one another on the same phenyl ring. These complexes are useful in rendering the hydroquinones more water-dispersible to assist their incorporation into photographic products. Also, the diamides may be incorporated into photographic products to reduce or eliminate various problems associated with hydroquinones, including migration of hydroquinones within the product during storage and the discoloration of images on storage due to oxidation of hydroquinone present in an image-receiving element of the photographic product.

  对苯二酚与芳香族二羧酸的 N,N,N',N'-四取代二酰胺形成稳定的氢键络合物，其中的两个羧基在同一苯环上相互对位排列。这些络合物可以使对苯二酚更容易在水中分散，从而有助于将其加入到感光产品中。此外，二酰胺还可以加入到感光产品中，以减少或消除与对苯二酚有关的各种问题，包括对苯二酚在储存过程中在产品内部的迁移，以及由于感光产品的图像接收元件中存在的对苯二酚氧化而导致图像在储存过程中变色。
• N₂ Extrusion and CO Insertion: A Novel Palladium-Catalyzed Carbonylative Transformation of Aryltriazenes
  作者：Wanfang Li、Xiao-Feng Wu

  DOI：10.1021/acs.orglett.5b00603

  日期：2015.4.17

  A novel procedure for the replacement of N-2 with CO of aryltriazenes has been developed. Aryltriazenes were converted to the corresponding arylamides catalyzed by 1 mol % of PdCl2/P(o-Tol)(3) under CO pressure. In this process, aryldiazonium salts were generated in the presence of 40 mol % of MeSO3H. Nitrogen was released from the substrates and CO formally inserted. Aryl bromides, iodides, alkynes, and free hydroxyl groups can be tolerated in this transformation.