2-(4-hydroxy-3-methoxyphenyl)-2-hydroxy-N-nonylacetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-(4-hydroxy-3-methoxyphenyl)-2-hydroxy-N-nonylacetamide
• 英文别名: 2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-N-nonylacetamide
• 化学式: C₁₈H₂₉NO₄
• 分子量: 323.433
• InChiKey: VLQILVXLCAQFNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  23
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  78.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  壬胺 、 3-甲氧基-4-羟基扁桃酸 在 N-羟基丁二酰亚胺 、 N,N'-二环己基碳二亚胺 作用下， 生成 2-(4-hydroxy-3-methoxyphenyl)-2-hydroxy-N-nonylacetamide
  参考文献：
  名称：

  [DE] VERWENDUNG VON MANDELSÄUREALKYLAMIDEN ALS AROMASTOFFE
  [EN] USE OF ALKYLAMIDOMANDELATES AS FLAVOURINGS
  [FR] UTILISATION D'ALKYLAMIDES D'ACIDE MANDELIQUE COMME AROMATISANTS

  摘要：

  这项发明描述了不同的杏仁酸烷酰胺及其作为辛辣物质和具有产热效应的香料的用途，优选用于食品、口腔卫生或享用的制剂。

  公开号：

  WO2003106404A1

文献信息

• VERWENDUNG VON MANDELSÄUREALKYLAMIDEN ALS AROMASTOFFE
  申请人：Symrise GmbH & Co. KG

  公开号：EP1515943B1

  公开（公告）日：2006-08-30
• Use of alkylamidomandelates as flavourings
  申请人：Ley P. Jakob

  公开号：US20050208084A1

  公开（公告）日：2005-09-22

  The present invention describes various mandelic acid alkylamides and their use as pungent compounds and flavour compounds with a heat-generating effect, preferably in preparations for use in nutrition, oral hygiene or consumed for pleasure.
• Use of a liquid cooling sensate to provide a pungent, warming or tingling sensate composition
  申请人：Moza Ashok K

  公开号：US20080038386A1

  公开（公告）日：2008-02-14

  The present invention is directed to a sensate composition consisting of a liquid cooling composition, and at least one warming, tingling, or pungent sensate ingredient of either synthetic or natural origin which provides enhanced warming, tingling, or pungent properties. The liquid cooling sensate of the invention is a eutectic mixture of 2-Isopropyl-N,2,3-trimethylbutyramide and N-Ethyl-p-menthane-3-carboxamide, or at least one cooling agent selected from the group consisting of N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutanamide, N-(3-ethoxypropyl)-2,3-dimethyl-2-isopropylbutanamide, N-(3-isopropoxypropyl)-2,3-dimethyl-2-isopropylbutanamide, N-(3-butoxypropyl)-2,3-dimethyl-2-isopropylbutanamide,N-Ethyl-2,2-diisopropylbutanamide, N-(1,1-dimethyl-2-hydroxyethyl)-2,2-diethylbutanamide, N-(2-ethoxyethyl)-2,3-dimethyl-2-isopropylbutanamide and N-(3-methoxypropyl)-2,3-dimethyl-2-isopropylbutanamide. The warming, tingling, or pungent sensate of the invention consists of at least one component that is an isothiocyanate and/or an amide or a natural product that contains at least one warming, tingling, or pungent principle that is an isothiocyanate and/or an amide. The present invention is further directed to a method of using the sensate composition in a food, pharmaceutical or personal care product.