头孢曲秦丙二醇 | 57235-40-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 中文名称: 头孢曲秦丙二醇
• 中文别名: 丙二醇头孢曲秦
• 英文名称: Cefatrizine propylene glycolate
• 英文别名: (6R,7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-(2H-triazol-4-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;propane-1,2-diol
• CAS: 57235-40-2
• 化学式: C21H26N6O7S2
• 分子量: 538.6
• InChiKey: CKOIKOHDEYTLFR-PFBPGKLMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  266
• 氢给体数：
  7
• 氢受体数：
  12

文献信息

• GAMMA-AAPEPTIDES WITH POTENT AND BROAD-SPECTRUM ANTIMICROBIAL ACTIVITY
  申请人：Cai Jianfeng

  公开号：US20150274782A1

  公开（公告）日：2015-10-01

  The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.

  本发明涉及一种新型类别的抗微生物药物，称为γ-AA肽。当前发明提供了各种类别的γ-AA肽，例如线性γ-AA肽、环状γ-AA肽和脂质化γ-AA肽。本发明的γ-AA肽被设计为具有抗微生物活性，同时稳定且无毒。γ-AA肽似乎也不会导致被治疗微生物体内微生物产生抗药性。因此，所披露的γ-AA肽可用于治疗与病原微生物相关的各种医疗状况。
• External preparation for skin diseases containing nitroimidazole
  申请人：——

  公开号：US20030092754A1

  公开（公告）日：2003-05-15

  An external preparation for skin disease which comprises a nitroimidazole derivative represented by the following formula (I): 1 wherein R 1 , R 3 and R 4 may be the same or different and represent a hydrogen atom, a nitro group, a lower alkyl group, a substituted lower alkyl group, a lower alkenyl group, or a substituted lower alkenyl group; and R 2 represents a hydrogen atom, a lower alkyl group, a substituted lower alkyl group and a lower alkenyl group or a substituted lower alkenyl group, provided that any one of R 1 , R 3 and R 4 is a nitro group.

  一种外用制剂，用于皮肤疾病，包括以下式(I)所代表的硝基咪唑衍生物：1其中R1、R3和R4可以相同也可以不同，并表示氢原子、硝基、低烷基、取代的低烷基、低烯基或取代的低烯基；R2表示氢原子、低烷基、取代的低烷基和低烯基或取代的低烯基，只要R1、R3和R4中的任何一个是硝基。
• CRYSTALLINE CONDITION DISLOCATING METHOD
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0665009A1

  公开（公告）日：1995-08-02

  An object of this invention is to provide a method of dislocating the crystalline condition of crystalline medicine simply, speedily and homogeneously, and, moreover, in large quantities at once. This invention is directed to a method using an extruder when crystalline medicine in a certain crystalline condition (△ is dislocated to another crystalline condition (○), i.e., when the dislocation of crystalline condition (△->○) is carried out.

  本发明的目的是提供一种简单、快速和均匀地将结晶药物的结晶状态变位的方法，而且是一次性大量变位。本发明针对的是一种使用挤压机将某种结晶状态（△）的结晶药物变位到另一种结晶状态（○）的方法，即结晶状态（△->○）变位的方法。
• Medical device and production method thereof
  申请人：UNITIKA LTD.

  公开号：EP0882461A2

  公开（公告）日：1998-12-09

  A medical device having both physiological and antimicrobial activity, comprising a base material, a cross-linked coating film formed on a surface of the base material, and each of a physiologically active substance and an antimicrobial substance bonded to the coating film. Also disclosed is a method for producing the medical device, which comprises providing a base material, forming a cross-linked coating film comprising the reaction product of a high molecular weight substance having acid anhydride groups and a compound having two or more active hydrogen atoms on a surface of the base material, and subsequently bonding each of a physiologically active substance and an antimicrobial substance to the coating film.

  一种同时具有生理活性和抗菌活性的医疗器械，包括基体材料、在基体材料表面形成的交联涂膜，以及粘合在涂膜上的生理活性物质和抗菌物质。还公开了一种生产该医疗设备的方法，该方法包括提供基体材料，在基体材料表面形成交联涂膜，该涂膜由具有酸酐基团的高分子量物质和具有两个或两个以上活性氢原子的化合物的反应产物组成，随后将生理活性物质和抗菌物质中的每一种粘合到涂膜上。
• LIPOSOMES
  申请人：TERUMO KABUSHIKI KAISHA

  公开号：EP1190706A1

  公开（公告）日：2002-03-27

  Drug carriers that includes a drug, being very high in targeting capability at a diseased site such as an inflammatory site or a tumor site where pH has been decreased in acidic regions. A liposome, comprising as membrane constituents [1] a basic compound, [2] an acidic compound which is a phosphoric acid monoester derivative, or a compound having a carboxyl group or its salt, and [3] other liposome constituent.

  药物载体，包括药物，在酸性区域 pH 值降低的炎症部位或肿瘤部位等病变部位具有很强的靶向能力。一种脂质体，其膜成分包括[1]碱性化合物，[2]磷酸单酯衍生物或具有羧基的化合物或其盐类的酸性化合物，以及[3]其他脂质体成分。