头孢来星二水合物 | 22202-75-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 中文名称: 头孢来星二水合物
• 英文名称: Cephaloglycin dihydrate
• 英文别名: (6R,7R)-3-(acetyloxymethyl)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;dihydrate
• CAS: 22202-75-1
• 化学式: C18H23N3O8S
• 分子量: 441.5
• InChiKey: KURFSUDYQUKEJZ-SBMYYUOMSA-N

物化性质

• 熔点：
  223-250° (dec)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.66
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  166
• 氢给体数：
  5
• 氢受体数：
  10

文献信息

• N-(6-((acylaminoacylamino or aminoacylamino)phenyl)-1,2-dihydro-2-oxonicotinyl) cephalosporin compounds, processes for their production, and compositions containing the same
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0015771A1

  公开（公告）日：1980-09-17

  N-[6-[(acylaminoacylamino or aminoacylamino) phenyl]-1,2-dihydro-2-oxonicotinyl] cephalosporin compounds having the formula: wlth broad spectrum antibacterial utility are provided, which can be produced by (a) reacting the free amino acid of the appropriate cephalosporin or the acid salt or silylated derivative or complex thereof with a reactive derivative of the corresponding N-6-[(acylaminoacylamino or aminoacylamino)phenyl]-1,2-dihydro-2-oxonicotinic acid, or (b) reacting the free amino acid 7-aminocephalosporanic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-[(acylaminoacylamino or aminoacylamino)phenyl]-1,2-dihydro-2-oxonicotinyl]-2-substituted glycine. Pharmaceutical compositions containing the novel compounds and methods for treating infections using such compositions are also disclosed.

  提供了 N-[6-[(酰氨基乙酰氨基或氨基乙酰氨基)苯基]-1,2-二氢-2-氧代烟酸基]头孢菌素化合物，其化学式如下： 提供了具有广谱抗菌效用的头孢菌素化合物，该化合物可通过 (a) 将相应头孢菌素的游离氨基酸或其酸盐或硅烷化衍生物或络合物与相应的 N-6-[(酰氨基乙酰氨基或氨基乙酰氨基)苯基]-1.N-6-[(酰氨基乙酰氨基或氨基乙酰氨基)苯基]-2-二氢-2-氧代烟酸酯的活性衍生物反应而制得，该化合物具有以下式子或 (b) 将游离氨基酸 7-氨基头孢烷酸或其相关化合物或其酸盐或硅烷基化衍生物与相应的 D-N-[6-[（酰氨基乙酰氨基或氨基乙酰氨基）苯基]-1,2-二氢-2-氧代烟酸基]-2-取代甘氨酸的活性衍生物反应。此外，还公开了含有新型化合物的药物组合物以及使用此类组合物治疗感染的方法。
• Stable plurilamellar vesicles
  申请人：THE LIPOSOME COMPANY, INC.

  公开号：EP0092453A2

  公开（公告）日：1983-10-26

  A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same. SPLVs are stable during storage and can be used in vivo for the sustained release of compounds and in the treatment of disease.

  本文介绍了一种新型的、经过重大改进的脂质囊泡--稳定多核酰胺囊泡（SPLVs）及其制造工艺。SPLV 在储存过程中非常稳定，可用于体内化合物的持续释放和疾病治疗。
• Use of oxygen antagonists for the therapeutic treatment of mammals
  申请人：Fred Hutchinson Cancer Research Center

  公开号：EP2363022A2

  公开（公告）日：2011-09-07

  There is provided the use of oxygen antagonists for inducing stasis in cells, tissues and/or organs in vivo or in an organism overall. It includes methods and apparatuses for achieving stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia and cancer is provided.

  本发明提供了使用氧拮抗剂诱导体内或整个生物体内的细胞、组织和/或器官停滞的方法。它包括在任何这些生物材料中实现停滞的方法和装置，以便保存和/或保护它们。在具体的实施方案中，提供了用于器官移植、热疗、伤口愈合、失血性休克、旁路手术的心脏麻痹、神经变性、低体温和癌症的治疗方法和装置。
• USE OF OXYGEN ANTAGONISTS FOR EX VIVO PRESERVATION OF TISSUES OR ORGANS
  申请人：Fred Hutchinson Cancer Research Center

  公开号：EP2949212A1

  公开（公告）日：2015-12-02

  There is provided the use of oxygen antagonists for inducing stasis in cells, tissues and/or organs in vivo or in an organism overall. It includes methods and apparatuses for achieving stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia and cancer is provided.

  本发明提供了使用氧拮抗剂诱导体内或整个生物体内的细胞、组织和/或器官停滞的方法。它包括在任何这些生物材料中实现停滞的方法和装置，以便保存和/或保护它们。在具体的实施方案中，提供了用于器官移植、热疗、伤口愈合、失血性休克、旁路手术的心脏麻痹、神经变性、低体温和癌症的治疗方法和装置。
• Methods, compositions and devices for inducing stasis in cells, tissues, organs, and organisms
  申请人：Roth B. Mark

  公开号：US20050136125A1

  公开（公告）日：2005-06-23

  The present invention concerns the use of oxygen antagonists for inducing stasis in cells, tissues, and/or organs in vivo or in an organism overall. It includes methods and apparatuses for achieving stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer is provided.

  本发明涉及使用氧拮抗剂诱导体内或整个生物体内的细胞、组织和/或器官停滞。它包括在任何这些生物材料中实现停滞的方法和装置，以便保存和/或保护它们。在具体的实施方案中，提供了用于器官移植、热疗、伤口愈合、失血性休克、旁路手术的心脏麻痹、神经变性、低体温和癌症的治疗方法和装置。