ethyl 2-c-(4-nitrophenyl)-3-triethylsilyl-1,4-oxathiane-3-r-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 2-c-(4-nitrophenyl)-3-triethylsilyl-1,4-oxathiane-3-r-carboxylate
• 英文别名: ethyl (2R,3R)-2-(4-nitrophenyl)-3-triethylsilyl-1,4-oxathiane-3-carboxylate
• 化学式: C₁₉H₂₉NO₅SSi
• 分子量: 411.594
• InChiKey: MESBTZSJQMJKJY-MJGOQNOKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.75
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  107
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  三乙基硅基三氟甲磺酸酯 在 copper acetylacetonate N,N-二异丙基乙胺 作用下， 以 乙醚 、 苯 为溶剂， 反应 22.0h， 生成 ethyl 2-c-(4-nitrophenyl)-3-triethylsilyl-1,4-oxathiane-3-r-carboxylate
  参考文献：
  名称：

  Conversion of 1,3-oxathiolanes to 1,4-oxathianes using a silylated diazoester

  摘要：

  Treatment of substituted 1,3-oxathiolanes with ethyl (triethylsilyl)diazoacetate in the presence of a copper catalyst effects one-carbon ring expansion to the corresponding 3-triethylsilyl-1,4-oxathiane-3-carboxylates. Subsequent desilylation can be brought about by treatment with tetrabutyl ammonium fluoride. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.10.063

文献信息

• Conversion of 1,3-oxathiolanes to 1,4-oxathianes using a silylated diazoester
  作者：Maria Ioannou、Michael J. Porter、Fabienne Saez

  DOI：10.1016/j.tet.2004.10.063

  日期：2005.1

  Treatment of substituted 1,3-oxathiolanes with ethyl (triethylsilyl)diazoacetate in the presence of a copper catalyst effects one-carbon ring expansion to the corresponding 3-triethylsilyl-1,4-oxathiane-3-carboxylates. Subsequent desilylation can be brought about by treatment with tetrabutyl ammonium fluoride. (C) 2004 Elsevier Ltd. All rights reserved.