1,1'-(dotriacontane-1,32-dioyl)bis[1-(12-methoxydodecanoyl)-sn-glycero-3-phosphocholine]

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 1,1'-(dotriacontane-1,32-dioyl)bis[1-(12-methoxydodecanoyl)-sn-glycero-3-phosphocholine]
• 英文别名: [(2R)-2-(12-methoxydodecanoyloxy)-3-[32-[(2R)-2-(12-methoxydodecanoyloxy)-3-[oxido-[2-(trimethylazaniumyl)ethoxy]phosphoryl]oxypropoxy]-32-oxodotriacontanoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
• 化学式: C₇₄H₁₄₆N₂O₁₈P₂
• 分子量: 1413.92
• InChiKey: BWUWRZUBIZJBOQ-FAECOVEHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  20.3
• 重原子数：
  96
• 可旋转键数：
  79
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  241
• 氢给体数：
  0
• 氢受体数：
  18

反应信息

• 作为产物：
  描述：

  12-羟基十二酸 在 palladium on activated charcoal 四氮唑 、 4-二甲氨基吡啶 、 四甲基乙二胺 、 氢气 、 双氧水 、 氧气 、 sodium hydride 、 N,N'-二环己基碳二亚胺 、 copper(l) chloride 作用下， 以 乙醇 、 二氯甲烷 、 溶剂黄146 、 甲苯 、 乙腈 、 xylene 为溶剂， 反应 49.5h， 生成 1,1'-(dotriacontane-1,32-dioyl)bis[1-(12-methoxydodecanoyl)-sn-glycero-3-phosphocholine]
  参考文献：
  名称：

  Synthesis of Defective Phospholipids

  摘要：

  Phospholipids have been synthesized that possess a normal 16-carbon chain plus a ''defective'' chain only 8 or 12 carbons long and terminated with methoxyl, hydroxyl, or carboxyl groups. In addition, dimeric phospholipids have been prepared in which two phospholipid units are joined at position-1 with chains of 22 or 32 carbons while unconnected chains at position-2 are, once again, short and functionalized. These phospholipids are potentially useful for constructing membranes that contain cavities or irregularities and, therefore, are capable of serving as self-assembled host systems in which drugs and other guest molecules are retained and, perhaps, eventually released.

  DOI：

  10.1021/jo9605455

文献信息

• Synthesis of Defective Phospholipids
  作者：Fredric M. Menger、Yue-Ling Wong

  DOI：10.1021/jo9605455

  日期：1996.1.1

  Phospholipids have been synthesized that possess a normal 16-carbon chain plus a ''defective'' chain only 8 or 12 carbons long and terminated with methoxyl, hydroxyl, or carboxyl groups. In addition, dimeric phospholipids have been prepared in which two phospholipid units are joined at position-1 with chains of 22 or 32 carbons while unconnected chains at position-2 are, once again, short and functionalized. These phospholipids are potentially useful for constructing membranes that contain cavities or irregularities and, therefore, are capable of serving as self-assembled host systems in which drugs and other guest molecules are retained and, perhaps, eventually released.