(2'S,4R)-spiro[chromane-4,1'-cyclopropane]-2'-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (2'S,4R)-spiro[chromane-4,1'-cyclopropane]-2'-carboxylic acid
• 英文别名: Rac-(3'R,4S)-2,3-dihydrospiro[1-benzopyran-4,1'-cyclopropane]-3'-carboxylicacid；(1'S,4R)-spiro[2,3-dihydrochromene-4,2'-cyclopropane]-1'-carboxylic acid
• 化学式: C₁₂H₁₂O₃
• 分子量: 204.225
• InChiKey: JXJOMJKPHPZPAD-BXKDBHETSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2'S,4R)-spiro[chromane-4,1'-cyclopropane]-2'-carboxylic acid 在 N-羟基-7-氮杂苯并三氮唑 、 二氧化碳 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 20.0~30.0 ℃ 、10.0 MPa 条件下， 反应 16.0h， 生成 (1S,3aR,4S,7R,7aS)-N-((S)-1-amino-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-((2'R,4S)-spiro[chromane-4,1'-cyclopropane]-2'-carbonyl)-2,3,3a,4,7,7a-hexahydro-1H-4,7-methanoisoindole-1-carboxamide
  参考文献：
  名称：

  [EN] ANTI-VIRAL COMPOUNDS
  [FR] COMPOSÉS ANTI-VIRAUX

  摘要：

  Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

  公开号：

  WO2023283256A1
• 作为产物：
  描述：

  ethyl rac-trans-spiro[chromane-4,1'-cyclopropane]-2'-carboxylate 在 水 、 lithium hydroxide 作用下， 以 甲醇 、 乙二醇二甲醚 为溶剂， 以98 %的产率得到(2'S,4R)-spiro[chromane-4,1'-cyclopropane]-2'-carboxylic acid
  参考文献：
  名称：

  [EN] ANTI-VIRAL COMPOUNDS
  [FR] COMPOSÉS ANTI-VIRAUX

  摘要：

  Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

  公开号：

  WO2023283256A1

文献信息

• [EN] SPIROCYCLOPROPYLAMINE DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASES KDM1A<br/>[FR] DÉRIVÉS DE SPIROCYCLOPROPYLAMINE UTILES EN TANT QU'INHIBITEURS D'HISTONE DÉMÉTHYLASES KDM1A
  申请人：IEO - ST EUROPEO DI ONCOLOGIA S R L

  公开号：WO2017109061A1

  公开（公告）日：2017-06-29

  The present invention relates to provided spirocyclopropylamine compounds, endowed with a potent KDM1A (LSD1) inhibitory activity, wherein X, R, and R1 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.

  本发明涉及提供的螺环环丙胺化合物，具有强效的KDM1A（LSD1）抑制活性，其中X、R和R1如规范中所定义，包含这种化合物的药物组合物以及它们在治疗中的应用。
• [EN] ANTI-VIRAL COMPOUNDS<br/>[FR] COMPOSÉS ANTI-VIRAUX
  申请人：[en]ALIGOS THERAPEUTICS, INC.

  公开号：WO2023283256A1

  公开（公告）日：2023-01-12

  Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.