nicotinic acid-(2,4-dihydroxy-benzylidenehydrazide)

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: nicotinic acid-(2,4-dihydroxy-benzylidenehydrazide)
• 英文别名: Nicotinsaeure-(2,4-dihydroxy-benzylidenhydrazid)；CD-20；N'-(2,4-dihydroxybenzylidene)nicotinohydrazide；N-[(E)-(2,4-dihydroxyphenyl)methylideneamino]pyridine-3-carboxamide
• 化学式: C₁₃H₁₁N₃O₃
• 分子量: 257.249
• InChiKey: YKUFPSNDHXRMFP-OVCLIPMQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-吡啶甲酰肼 、 2,4-二羟基苯甲醛 以 N,N-二甲基甲酰胺 为溶剂， 生成 nicotinic acid-(2,4-dihydroxy-benzylidenehydrazide)
  参考文献：
  名称：

  Design, synthesis and in vitro antimalarial activity of an acylhydrazone library

  摘要：

  A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the iron chelator in widespread clinical use and also than the most effective chelators. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.09.058

文献信息

• Luedy-Tenger, Mikrochimica acta, 1956, p. 104,112
  作者：Luedy-Tenger

  DOI：——

  日期：——
• HEME OXYGENASE INHIBITORS, SCREENING METHODS FOR HEME OXYGENASE INHIBITORS AND METHODS OF USE OF HEME OXYGENASE INHIBITORS FOR ANTIMICROBIAL THERAPY
  申请人：Wilks Angela

  公开号：US20100081661A1

  公开（公告）日：2010-04-01

  Inhibitors of microbial heme oxygenase and their use for treatment of microbial infections and bioremediation. The inhibitors of microbial heme oxygenase are useful against a new class of antimicrobial agents to target infections that are persistently difficult to combat with the current spectrum of antimicrobial agents. Screening methods for selecting inhibitors of microbial heme oxygenase.
• US8450368B2
  申请人：——

  公开号：US8450368B2

  公开（公告）日：2013-05-28
• [EN] COMPOUNDS AND METHODS FOR PREVENTION AND TREATMENT OF ALZHEIMER'S AND OTHER DISEASES<br/>[FR] COMPOSÉS ET PROCÉDÉS POUR LA PRÉVENTION ET LE TRAITEMENT DE LA MALADIE D'ALZHEIMER ET D'AUTRES MALADIES
  申请人：THE FEINSTEIN INST MEDICAL RES

  公开号：WO2012027548A1

  公开（公告）日：2012-03-01

  Small molecule activators of AMPK and methods of preventing and treating diseases such as Alzheimer's disease, protein conformation disorders, cancer, diabetes, obesity and metabolic syndrome using these compounds are provided.
• Design, synthesis and in vitro antimalarial activity of an acylhydrazone library
  作者：Patricia Melnyk、Virginie Leroux、Christian Sergheraert、Philippe Grellier

  DOI：10.1016/j.bmcl.2005.09.058

  日期：2006.1

  A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the iron chelator in widespread clinical use and also than the most effective chelators. (c) 2005 Elsevier Ltd. All rights reserved.