N-phthaloylglycine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phthaloylglycine
• 英文别名: phthaloylglycine；phthalylglycine；Phthaloylglycine；2-[(2-Formylbenzoyl)amino]acetic acid；2-[(2-formylbenzoyl)amino]acetic acid
• 化学式: C₁₀H₉NO₄
• 分子量: 207.186
• InChiKey: RWBFZINNNGURDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  83.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-phthaloylglycine 在 氯化亚砜 作用下， 以 水 为溶剂， 生成 N-邻苯二甲酰甘氨酰氯
  参考文献：
  名称：

  Metal chelates of substituted polyaminocarboxylic macrocycles and their use in diagnostic imaging

  摘要：

  将式I中R为含有3或4个连续苯环的亲水基团，m为1或2的化合物与金属离子螯合，用于诊断成像。

  公开号：

  US06187285B1

文献信息

• Boronic Acid Catalysts and Methods of Use Thereof for Activation and Transformation of Carboxylic Acids
  申请人：Hall Dennis

  公开号：US20140142322A1

  公开（公告）日：2014-05-22

  The present application provides methods and catalysts for activation of carboxylic acids for organic reactions. In particular, methods are disclosed for direct nucleophilic addition reactions, such as, amidation reactions with amines, cycloadditions, and conjugate additions, using boronic acid catalysts of formula I, II or III: Also included are novel boronic acid catalysts of formula IV, V and III:

  本申请提供了激活羧酸进行有机反应的方法和催化剂。具体而言，揭示了使用式I、II或III的硼酸催化剂进行直接亲核加成反应的方法，例如与胺的酰胺化反应、环加成反应和共轭加成反应。还包括式IV、V和III的新型硼酸催化剂。
• A convenient synthesis of 2-azetidinones via 2-fluoro-1-methylpyridinium p-toluenesulfonate
  作者：Maaroof Zarei

  DOI：10.1007/s00706-012-0918-y

  日期：2013.7

  The application and versatility of 2-fluoro-1-methylpyridinium p-toluenesulfonate as acid activator in the synthesis of several beta-lactams under mild reaction conditions by use of ketene-imine cycloaddition reactions has been investigated. The effects of solvents, molar ratio of reagents, and temperature were considered. The method was also used for preparation of beta-lactams substituted in position 3 by electron-withdrawing groups. The products are obtained in good to excellent yields..
• Metal chelates of substituted polyaminocarboxylic macrocycles and their use in diagnostic imaging
  申请人：Guerbet

  公开号：US06187285B1

  公开（公告）日：2001-02-13

  Chelates of the compounds of formula I in which R is a hydrophilic group containing 3 or 4 successive phenyl rings and m is 1 or 2, with metal ions, for use in diagnostic imaging.

  将式I中R为含有3或4个连续苯环的亲水基团，m为1或2的化合物与金属离子螯合，用于诊断成像。