sodium 4-(bromomethyl)phenylcarboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: sodium 4-(bromomethyl)phenylcarboxylate
• 英文别名: Sodium-4-(bromomethyl)benzoate；sodium;4-(bromomethyl)benzoate
• 化学式: C₈H₆BrO₂*Na
• 分子量: 237.028
• InChiKey: WJPOAFLWYKDNIB-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.05
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-巯基吡啶钠盐 、 sodium 4-(bromomethyl)phenylcarboxylate 以 甲醇 为溶剂， 反应 12.0h， 以51%的产率得到sodium (4-sulfanylmethyl-4'-phenylcarboxylate pyridine)
  参考文献：
  名称：

  A novel coordination polymer containing puckered rhombus grids

  摘要：

  聚合物配合物 [Ni(spcp)2]n (spcp− = 4-硫烷基甲基-4'-苯甲酸吡啶），其尺寸为 11.72 × 11.09 Å 的褶皱菱形网格是由 Ni(OAc)2·4H2O 与 Na(spcp) 通过溶剂热法反应获得的。

  DOI：

  10.1039/b108449f

文献信息

• Zwitterionic polymers
  申请人：——

  公开号：US20040063881A1

  公开（公告）日：2004-04-01

  Polymers may be made from zwitterionic monomers having controlled architectures and molecular weights, using living polymerisations such as group or atom transfer radical polymerisation. For instance polymers may be formed by atom transfer radical polymerisation using a copper chloride catalyst, a ligand which is water soluble, and a water soluble tertiary alkyl halide initiator to form homopolymers having controlled polydispersities of less than 1.5 and block copolymers with other hydrophilic or hydrophobic monomers. One suitable zwitterionic monomer is 2-methacryloyloxy-2′-trimethylammoniumethyl phosphate inner salt. The block copolymers may spontaneously form micelles, believed to have zwitterionic, for instance phosphorylcholine, groups at the external surface, which may be useful as drug delivery systems with improved biocompatibility.

  聚合物可由具有可控结构和分子量的齐聚物单体通过活聚合（如基团或原子转移自由基聚合）制成。例如，可以使用氯化铜催化剂、水溶性配体和水溶性叔烷基卤化物引发剂，通过原子转移自由基聚合反应形成聚合物，从而形成聚分散度小于 1.5 的均聚物以及与其他亲水或疏水单体的嵌段共聚物。一种合适的齐聚物单体是 2-甲基丙烯酰氧基-2′-三甲基乙基磷酸铵内盐。嵌段共聚物可以自发地形成胶束，据信胶束的外表面具有例如磷酰胆碱基团的齐聚物，这种胶束可以用作药物输送系统，具有更好的生物相容性。
• ZWITTERIONIC POLYMERS
  申请人：Biocompatibles UK Limited

  公开号：EP1325046A1

  公开（公告）日：2003-07-09
• US6852816B2
  申请人：——

  公开号：US6852816B2

  公开（公告）日：2005-02-08
• US7300990B2
  申请人：——

  公开号：US7300990B2

  公开（公告）日：2007-11-27
• [EN] ZWITTERIONIC POLYMERS<br/>[FR] POLYMERES ZWITTERIONIQUES
  申请人：BIOCOMPATIBLES LTD

  公开号：WO2002028929A1

  公开（公告）日：2002-04-11

  Polymers may be made from zwitterionic monomers having controlled architectures and molecular weights, using living polymerisations such as group or atom transfer radical polymerisation. For instance polymers may be formed by atom transfer radical polymerisation using a copper chloride catalyst, a ligand which is water soluble, and a water soluble tertiary alkyl halide initiator to form homopolymers having controlled polydispersities of less than 1.5 and block copolymers with other hydrophilic or hydrophobic monomers. One suitable zwitterionic monomer is 2-methacryloyloxy-2'-trimethylammoniumethyl phosphate inner salt. The block copolymers may spontaneously form micelles, believed to have zwitterionic, for instance phosphorylcholine, groups at the external surface, which may be useful as drug delivery systems with improved biocompatibility.