1-phenyl-4-(3-ethyl-pyridin-4-yl)-1,3-butadiene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-phenyl-4-(3-ethyl-pyridin-4-yl)-1,3-butadiene
• 英文别名: 1-phenyl-4-(3-ethyl-4-pyridyl)-1,3-butadiene；3-ethyl-4-[(1E,3E)-4-phenylbuta-1,3-dienyl]pyridine
• 化学式: C₁₇H₁₇N
• 分子量: 235.329
• InChiKey: PEGLAVLPRORCEU-JMQWPVDRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (E)-1-(3-ethylpyridin-4-yl)-4-phenylbut-3-en-2-ol 生成 1-phenyl-4-(3-ethyl-pyridin-4-yl)-1,3-butadiene
  参考文献：
  名称：

  TEHRADA, IDZUMI;MATSUDZAKI, KATSUXIKO;NONOSITA, KADZUESI;FUDZITA, FUMIO

  摘要：

  DOI：

文献信息

• Pyridine derivatives and insecticide and miticide comprising said
  申请人：Idemitsu Kosan Co., Ltd.

  公开号：US05262420A1

  公开（公告）日：1993-11-16

  A pyridine compound of the formula ##STR1## wherein X is a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxyl group having 1 to 4 carbon atoms, a haloalkyl group having 1 to 4 carbon atoms or a haloalkoxyl group having 1 to 4 carbon atoms, n is 1 to 5, and when n is 2 or more, Xs may be identical to or different from each other, A is an alkyl residue or alkene residue in which a portion connecting the aryl group with the 4-position of the pyridyl group has 3 to 8 carbon atoms, or an alkapolyene residue in which said portion has 4 to 8 carbon atoms and 2 to 4 double bonds; the alkyl residue, alkene residue, and alkapolyene residue may have an alkyl side chain having 1 to 4 carbon atoms, an alkylidene side chain having 1 to 4 carbon atoms or 1 to 16 halogen atoms, and when there are 2 or more side chains, the side chains may be identical to or different from each other, and R.sup.1 and R.sup.2 are each a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or salts thereof. The pyridine compounds and salts thereof exhibit a strong insecticidal and miticidal activity and are low in residuality and accumulativity and are thus useful as insecticides and miticides for the control of pests in agriculture and horticulture.

  一种杂环化合物，其分子式为##STR1##，其中X为氢原子、卤素原子、1至4个碳原子的烷基、1至4个碳原子的烷氧基、1至4个碳原子的卤代烷基或1至4个碳原子的卤代烷氧基；n为1至5，当n为2个或更多时，X可以相同也可以不同；A为连接芳基和吡啶基4位的部分含有3至8个碳原子的烷基残基或烯基残基，或含有4至8个碳原子和2至4个双键的烯丙基残基；烷基残基、烯基残基和烯丙基残基可以含有1至4个碳原子的烷基侧链、1至4个碳原子或1至16个卤素原子的亚烷基侧链，当存在2个或更多侧链时，侧链可以相同也可以不同；R1和R2各自为氢原子或含有1至6个碳原子的烷基，或其盐。这些杂环化合物及其盐类具有强烈的杀虫和杀螨活性，且残留性和积累性低，因此作为杀虫剂和杀螨剂用于农业和园艺中控制害虫非常有用。
• Synthesis and evaluation of a series of 1,4-Diarylbutadienes for anticoccidial activity
  作者：Jennifer L Gage、Herbert A Kirst、Deirdre O'Neil、Bridget A David、Charles K Smith、Sharon A Naylor

  DOI：10.1016/s0968-0896(03)00330-4

  日期：2003.9

  During the course of a collaborative screening program, a set of 1-phenyl-4-pyridyl-butadienes was found to exhibit in vitro activity against Eimeria tenella in a cell-based assay. Activity was dependent on the chain length and degree of unsaturation of the linker between the two aryl groups as well as substitution of the pyridine moiety. Structure-activity relationship studies were subsequently conducted

  在协作筛选程序的过程中，在基于细胞的测定中，发现一组1-苯基-4-吡啶基-丁二烯具有抗艾美尔球虫的体外活性。活性取决于两个芳基之间的链长和连接基的不饱和度以及吡啶部分的取代。随后在较大范围的1,4-二芳基丁二烯上进行了结构-活性关系研究，以确定活性化合物的范围，确定支配活性的结构模式并增强体外抗大肠杆菌的能力。另外，通过测试当通过强饲法给药时该化合物预防或减少肠和盲肠损伤的能力，来测量许多化合物治疗鸡球虫病的功效。
• PYRIDINE DERIVATIVES AND INSECTICIDAL AND MITICIDAL AGENT CONTAINING SAME AS ACTIVE INGREDIENT
  申请人：IDEMITSU KOSAN COMPANY LIMITED

  公开号：EP0383950A1

  公开（公告）日：1990-08-29

  Novel pyridine derivatives represented by general formula (I) and salts thereof are disclosed. In the said formula, X represents a hydrogen atom, a halogen atom, an alkyl group containing 1 to 4 carbon atoms, an alkoxy group or a haloalkoxy group, n represents an integer of 1 to 5, A represents an alkylene or alkenylene residue containing 3 to 8 carbon atoms or an alkapolyenylene residue containing 4 to 8 carbon atoms, which may optionally have an alkyl or alkylidene side chain containing 1 to 4 carbon atoms, or 1 to 16 halogen atoms, and R' and R2 each represents a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms. Also disclosed is an insecticidal and miticidal agent containing same as active ingredient which shows strong insecticidal and miticidal activities with reduced per- sistance and accumulation of its effect. and which can be effectively utilized for controlling harmful insects in agriculture and horticulture.

  本发明公开了通式(I)代表的新型吡啶衍生物及其盐类。在上述通式中，X 代表氢原子、卤素原子、含 1 至 4 个碳原子的烷基、烷氧基或卤代烷氧基，n 代表 1 至 5 的整数，A 代表含 3 至 8 个碳原子的亚烷基或烯基残基或含 4 至 8 个碳原子的亚烷基残基，可任选具有含 1 至 4 个碳原子的烷基或亚烷基侧链，或 1 至 16 个卤素原子，R'和 R2 各代表氢原子或含 1 至 6 个碳原子的烷基。本发明还公开了一种杀虫杀螨剂，其活性成分含有相同的杀虫杀螨剂，具有很强的杀虫杀螨活性，降低了抗药性和累积效应，可有效地用于农业和园艺业中控制有害昆虫。
• US5262420A
  申请人：——

  公开号：US5262420A

  公开（公告）日：1993-11-16