(Z)-1-{N-benzyl-N-[(1S)-phenylethyl]}amino-2-(p-methoxyphenyl)-1-trifluoromethylethylene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-1-{N-benzyl-N-[(1S)-phenylethyl]}amino-2-(p-methoxyphenyl)-1-trifluoromethylethylene
• 英文别名: (Z)-N-benzyl-3,3,3-trifluoro-1-(4-methoxyphenyl)-N-[(1S)-1-phenylethyl]prop-1-en-2-amine
• 化学式: C₂₅H₂₄F₃NO
• 分子量: 411.467
• InChiKey: HZFFOIBZXBJQDA-ODHYRZOZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (S)-(-)-N-苄基-1-苯基-乙胺 、 1-[2-氯-3,3,3-三氟-1-丙烯基]-4-甲氧基苯 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以95%的产率得到(Z)-1-{N-benzyl-N-[(1S)-phenylethyl]}amino-2-(p-methoxyphenyl)-1-trifluoromethylethylene
  参考文献：
  名称：

  Regio- and stereoselective synthesis of chiral (αS)-(Z)-trifluoromethyl-β-aryl-enamines

  摘要：

  Chiral (alphaS)-(Z)-trifluoromethyl-beta-aryl-enamines were regio and stereoselectiveally prepared in excellent yields by the one pot reaction of 2-aryl-1-chloro-1-trifluoromethylethlene with lithium (alphaS)-(alpha-methylbenzyl) benzylamide. A mechanism involving elimination and addition processes is discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)01156-5

文献信息

• Regio- and stereoselective synthesis of chiral (αS)-(Z)-trifluoromethyl-β-aryl-enamines
  作者：Biao Jiang、Fangjiang Zhang、Wennan Xiong

  DOI：10.1016/s0040-4020(01)01156-5

  日期：2002.1

  Chiral (alphaS)-(Z)-trifluoromethyl-beta-aryl-enamines were regio and stereoselectiveally prepared in excellent yields by the one pot reaction of 2-aryl-1-chloro-1-trifluoromethylethlene with lithium (alphaS)-(alpha-methylbenzyl) benzylamide. A mechanism involving elimination and addition processes is discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.