(+)-N,O-二去甲基曲马多 | 144830-18-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (+)-N,O-二去甲基曲马多
• 英文名称: O,N-didesmethyltramadol
• 英文别名: 3-[(1R,2R)-1-hydroxy-2-(methylaminomethyl)cyclohexyl]phenol
• CAS: 144830-18-2
• 化学式: C₁₄H₂₁NO₂
• 分子量: 235.32
• InChiKey: CJXNQQLTDXASSR-OCCSQVGLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  52.5
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
  申请人：Sepracor Inc.

  公开号：EP2617704A1

  公开（公告）日：2013-07-24

  Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g. from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.

  本文公开了苯基取代的环己胺衍生物及其合成和表征方法。本文阐述了这些化合物在治疗/预防神经系统疾病方面的用途及其合成方法。本发明的示例化合物可抑制多巴胺、5-羟色胺和去甲肾上腺素等内源性单胺的再摄取（例如从突触间隙），并调节一种或多种单胺转运体。还提供了含有本发明化合物的药物制剂。
• PHENYL SUBSTITUTED CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS
  申请人：Shao Liming

  公开号：US20090005456A1

  公开（公告）日：2009-01-01

  Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.
• PHENYL SUBSTITUTED CYCLOALKYLAMINES AS MONOAMINE REPUTAKE INHIBITORS
  申请人：Sunovion Pharmaceuticals Inc.

  公开号：US20170204050A1

  公开（公告）日：2017-07-20

  Phenyl-substituted cyclohexylamine derivatives and methods for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.
• US8669291B2
  申请人：——

  公开号：US8669291B2

  公开（公告）日：2014-03-11
• US9586888B2
  申请人：——

  公开号：US9586888B2

  公开（公告）日：2017-03-07