(-)-(R)-N-(3,4-二氢-2H-1-苯并呋喃-2-基甲基)-N-[5-(4-氟苯基)-3-吡啶甲基]胺 | 177975-08-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: (-)-(R)-N-(3,4-二氢-2H-1-苯并呋喃-2-基甲基)-N-[5-(4-氟苯基)-3-吡啶甲基]胺
• 英文名称: N-[5-(4-fluorophenyl)-pyridin-3-ylmethyl]-N-(2-chromanyl-methyl)-amine
• 英文别名: (R)-(-)-2-[5-(4-fluorophenyl)-pyridin-3-yl methylaminomethyl]-chromane；N-[5-(4-fluorophenyl)-3-pyridylmethyl]-N-(2-chromanyl-methyl)-amine；N-((3,4-Dihydro-2H-1-benzopyran-2-yl)methyl)-5-(4-fluorophenyl)-3-pyridinemethanamine；1-(3,4-dihydro-2H-chromen-2-yl)-N-[[5-(4-fluorophenyl)pyridin-3-yl]methyl]methanamine
• CAS: 177975-08-5
• 化学式: C₂₂H₂₁FN₂O
• 分子量: 348.42
• InChiKey: HKFMQJUJWSFOLY-UHFFFAOYSA-N

物化性质

• 沸点：
  507.7±45.0 °C(Predicted)
• 密度：
  1.172±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  34.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Method for producing 5-aryl nicotinaldehydes
  申请人：——

  公开号：US20030055259A1

  公开（公告）日：2003-03-20

  The invention relates to a process for the preparation of 5-arylnicotinaldehydes by reduction of the corresponding 5-arylnicotinic acids by catalytic hydrogenation in the presence of carboxylic anhydrides in which the catalyst used is a palladium/ligand complex, characterized in that the molar ratio between palladium and ligand is from 1:5 to 1:15 in the case of monodentate ligands and from 1:2.5 to 1:7.5 in the case of bidentate ligands.

  该发明涉及一种通过在羧酸酐存在下催化氢化还原相应的5-芳基烟酸制备5-芳基烟醛的方法，所使用的催化剂为钯/配体复合物，其特征在于单齿配体情况下钯和配体之间的摩尔比为1:5至1:15，双齿配体情况下为1:2.5至1:7.5。
• Method for producing-2[-5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane
  申请人：——

  公开号：US20040138266A1

  公开（公告）日：2004-07-15

  The present invention relates to a process for the preparation of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, the enantiomers and its salts, characterised in that 5-(4-fluorophenyl)pyridine-3-carbaldehyde is reacted directly with aminomethylchroman or its salts under reducing conditions to give 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, and the latter is, if desired, converted into one of its physiologically acceptable salts by treatment with an acid.

  本发明涉及一种制备2 - [5-（4-氟苯基）-3-吡啶甲基氨甲基] 色满及其对映体和其盐的方法，其特征在于，5-（4-氟苯基）吡啶-3-甲醛在还原条件下直接与氨甲基色满或其盐反应，得到2 - [5-（4-氟苯基）-3-吡啶甲基氨甲基] 色满，如有需要，可以通过酸处理将其转化为其生理上可接受的盐之一。
• CHROMANONE DERIVATIVES
  申请人：——

  公开号：US20040092579A1

  公开（公告）日：2004-05-13

  Chromanone derivatives of the formula I 1 in which R 1 to R 4 are each, independently of one another, H, A, CN, Hal, OR 5 , COOR 5 , CF 3 , OCF 3 , NO 2 , Ar, OAr, N(R 5 ) 2 or CON(R 5 ) 2 , R 5 is H or A, A is alkyl having 1 to 6 carbon atoms, Ar is phenyl which is unsubstituted or substituted by A, OR 5 , CN, Hal, CF 3 , OCF 3 , NO 2 or N(R 5 ) 2 , Hal is F, Cl, Br or I, and their salts, are suitable as intermediates in the synthesis of medicaments.

  公式I1的Chromanone衍生物，其中R1至R4各自独立地为H，A，CN，Hal，OR5，COOR5，CF3，OCF3，NO2，Ar，OAr，N（R5）2或CON（R5）2，R5为H或A，A为具有1至6个碳原子的烷基，Ar为苯基，未取代或被A，OR5，CN，Hal，CF3，OCF3，NO2或N（R5）2取代，Hal为F，Cl，Br或I，其盐，在药物合成中作为中间体是合适的。
• NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION
  申请人：Barlow Carrolee

  公开号：US20070049576A1

  公开（公告）日：2007-03-01

  The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes compositions and methods based on muscarinic receptor modulation, such as via inhibition of acetylcholine esterase (AChE) activity, alone or in combination with another neurogenic agent to stimulate or activate the formation of new nerve cells.

  该即时披露描述了通过刺激或增加神经发生来治疗中枢神经系统和外周神经系统的疾病和病症的方法。该披露包括基于毒蕈碱受体调节的组合物和方法，例如通过抑制乙酰胆碱酯酶（AChE）活性，单独或与另一种神经生成剂结合以刺激或激活新神经细胞的形成。
• Amino(thio)ether derivatives as CNS active agents
  申请人：MERCK PATENT GmbH

  公开号：EP0707007A1

  公开（公告）日：1996-04-17

  Amino(thio)ether derivatives of formula I wherein R°, R¹, R², R³, R⁶, R⁷, R⁸, R⁹, X and Z are as defined in Claim 1, and their salts, are active on the central nervous system.

  式 I 的氨基（硫代）醚衍生物 其中 R°、R¹、R²、R³、R⁶、R⁷、R⁸、R⁹、X 和 Z 如权利要求 1 所定义，它们的盐类对中枢神经系统具有活性。