(12-溴十二烷基)膦酸 | 202920-07-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 中文名称: (12-溴十二烷基)膦酸
• 英文名称: 12-bromododecylphosphonic acid
• CAS: 202920-07-8
• 化学式: C₁₂H₂₆BrO₃P
• 分子量: 329.214
• InChiKey: OFBOCVJPIJRGMU-UHFFFAOYSA-N

物化性质

• 熔点：
  92-94℃
• 沸点：
  441.2±37.0 °C(Predicted)
• 密度：
  1.271±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  diethyl (12-bromododecyl)phosphonate 在 三甲基溴硅烷 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以89%的产率得到(12-溴十二烷基)膦酸
  参考文献：
  名称：

  PREPARATION OF AN INORGANIC SUBSTRATE HAVING ANTIMICROBIAL PROPERTIES

  摘要：

  本发明涉及一种用于修改无机基底的过程，旨在赋予其抗菌性能，该过程包括在所述基底表面上通过一步或多步嫁接具有固有抗菌性能或能释放具有抗菌性能的物种的基团。通过有机磷偶联剂进行嫁接。本发明的一个对象同样是通过这种过程获得的基底，以及这种基底的各种用途。

  公开号：

  US20100249425A1

文献信息

• Preparation of an inorganic substrate having antimicrobial properties
  申请人：Mutin Hubert

  公开号：US08586758B2

  公开（公告）日：2013-11-19

  The invention relates to a process for modifying an inorganic substrate, directed toward giving it antimicrobial properties, said process consisting in grafting in one or more steps onto a surface of said substrate groups with intrinsic antimicrobial properties or groups capable of releasing species with antimicrobial properties. The grafting is performed by means of an organophosphorus coupling agent. A subject of the invention is similarly a substrate obtained by this process, as well as diverse uses of such a substrate.

  本发明涉及一种改性无机基底的方法，旨在赋予其抗微生物性能，该方法包括在该基底的表面上通过一个或多个步骤嫁接具有固有抗微生物性能或能释放具有抗微生物性能的物质的基团。嫁接是通过有机磷偶联剂实现的。本发明的另一个方面是通过此方法获得的基底，以及此类基底的多种用途。
• PREPARATION D'UN SUBSTRAT INORGANIQUE PRESENTANT DES PROPRIETES ANTI-MICROBIENNES
  申请人：Centre National de la Recherche Scientifique

  公开号：EP1973583A1

  公开（公告）日：2008-10-01
• DRUG DELIVERY FROM IMPLANTS USING SELF-ASSEMBLED MONOLAYERS-THERAPEUTIC SAMS
  申请人：Agrawal C. Mauli

  公开号：US20090123516A1

  公开（公告）日：2009-05-14

  Disclosed are medical devices comprising one or more surfaces, one or more SAM molecules attached to the one or more surfaces of the medical device, and one or more therapeutic agents attached to the one or more self-assembled monolayer molecules. Also disclosed are medical devices comprising one or more surfaces, one or more self-assembled monolayer molecules attached to the one or more surfaces of the medical device, one or more linkers comprising a first functional group and a second functional group, the first functional group attached to the self-assembled monolayer molecule and a therapeutic agent attached to the second functional group. The therapeutic agent may be attached to the SAM molecule via a linker. The present invention also concerns methods of administering a therapeutic agent to a subject, comprising contacting the subject with one of the medical devices set forth herein.
• US8586758B2
  申请人：——

  公开号：US8586758B2

  公开（公告）日：2013-11-19
• [EN] DRUG DELIVERY FROM IMPLANTS USING SELF-ASSEMBLED MONOLAYERS - THERAPEUTIC SAMS<br/>[FR] LIBERATION DE MEDICAMENTS PAR DES IMPLANTS COMPRENANT DES MONOCOUCHES AUTO-ASSEMBLEES (SAM) SAM THERAPEUTIQUES
  申请人：UNIV TEXAS

  公开号：WO2007019478A2

  公开（公告）日：2007-02-15

  [EN] Disclosed are medical devices comprising one or more surfaces, one or more SAM molecules attached to the one or more surfaces of the medical device, and one or more therapeutic agents attached to the one or more self-assembled monolayer molecules. Also disclosed are medical devices comprising one or more surfaces, one or more self-assembled monolayer molecules attached to the one or more surfaces of the medical device, one or more linkers comprising a first functional group and a second functional group, the first functional group attached to the self-assembled monolayer molecule and a therapeutic agent attached to the second functional group. The therapeutic agent may be attached to the SAM molecule via a linker. The present invention also concerns methods of administering a therapeutic agent to a subject, comprising contacting the subject with one of the medical devices set forth herein.
  [FR] L'invention concerne des dispositifs médicaux comprenant une ou plusieurs surfaces, une ou plusieurs molécules SAM attachées à une ou plusieurs surfaces du dispositif médical, et un ou plusieurs agents thérapeutiques fixés sur les molécules de la ou des monocouches auto-assemblées. L'invention concerne en outre des dispositifs médicaux comprenant une ou plusieurs surfaces, une ou plusieurs molécules de monocouche auto-assemblée fixées à la surface ou aux surfaces du dispositif médical, un ou plusieurs lieurs comprenant un premier groupe fonctionnel et un second groupe fonctionnel, le premier groupe fonctionnel étant attaché à la molécule de la monocouche auto-assemblée, et un agent thérapeutique attaché au second groupe fonctionnel. L'agent thérapeutique peut être fixé sur la molécule SAMS par l'intermédiaire d'un lieur. L'invention porte également sur des procédés d'administration d'un agent thérapeutique à un sujet consistant appliquer un dispositif médical du type décrit à un sujet.