(1R,2R)-1-氟-2-甲氧基环己烷 | 65267-06-3

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 中文名称: (1R,2R)-1-氟-2-甲氧基环己烷
• 英文名称: fluoro-1, methoxy-2 cyclohexane (E)
• 英文别名: trans-1-Fluoro-2-methoxycyclohexane；trans-2-fluoro-1-methoxycyclohexane；1-Methoxy-2-fluorocyclohexane；(1R,2R)-1-Fluoro-2-methoxycyclohexane
• CAS: 65267-06-3；79186-49-5
• 化学式: C₇H₁₃FO
• 分子量: 132.178
• InChiKey: ZVARKDFRCWVEBF-RNFRBKRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  trans-2-methoxycyclohexyl-mercury(II) chloride 在 N-fluorobis<(trifluoromethyl)sulfonyl>imide 作用下， 以 乙腈 为溶剂， 反应 1.0h， 生成 (1R,2R)-1-氟-2-甲氧基环己烷
  参考文献：
  名称：

  N-Fluoro-bis[(trifluoromethyl)sulfonyl]imide: interesting reactions involving nucleophilic attack on sulfonyl groups

  摘要：

  N-Fluoro-bis[(trifluoromethyl)sulfonyl]imide (1) undergoes reaction with a variety of nucleophiles to give a number of interesting products. Under suitable conditions, the sulfonyl group on 1 is subject to nucleophilic attack forming N-fluoro-trifluoromethylsulfonyl amide (3) and Nu-SO2CF3. Surprisingly, 3 can also function as a weak nucleophile in the absence of other stronger bases. (C) 2000 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0022-1139(99)00231-6

文献信息

• Synthesis of fluoro ethers with acetyl hypofluorite
  作者：David Hebel、Shlomo Rozen

  DOI：10.1021/jo00388a046

  日期：1987.6
• The Chemistry of Methyl Hypofluorite: Its Reactions with Various Unsaturated Centers
  作者：Shlomo Rozen、Eyal Mishani、Moshe Kol、Iris Ben-David

  DOI：10.1021/jo00094a047

  日期：1994.7

  Methyl hypofluorite was until recently grouped as a hypothetical member of those smallest organic molecules which had not been synthesized. Passing F-2 through a solution of methanol in MeCN or PrCN resulted in its successful preparation. MeOF is an unique reagent, since it generates the novel electrophilic methoxylium moiety in contrast to the much more common methoxide group. This hypofluorite was reacted with several types of olefins including benzylic, cyclic, bicyclic, straight chain, and steroidal ones. In most cases the regioselectivity is very good, reflecting the unique polarization of the reagent: MeO(delta+)F(delta-). The stereoselectivity tends to be less emphasized, but usually anti addition is dominant.
• Synthese et proprietes d'ethers β-monofluores
  作者：A. Baklouti、M.M. Chaabouni

  DOI：10.1016/s0022-1139(00)82301-5

  日期：1981.7
• BAKLOUTI A.; CHAABOUNI M. M., J. FLUOR. CHEM., 1981, 18, NO 1, 45-56
  作者：BAKLOUTI A.、 CHAABOUNI M. M.

  DOI：——

  日期：——
• HEBEL D.; ROZEN SH., J. ORG. CHEM., 52,(1987) N 12, 2588-2590
  作者：HEBEL D.、 ROZEN SH.

  DOI：——

  日期：——