(1S)-2,2,2-三氟-1-[4-(三氟甲基)苯基]乙胺 | 785766-87-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (1S)-2,2,2-三氟-1-[4-(三氟甲基)苯基]乙胺
• 英文名称: (S)-2,2,2-Trifluoro-1-(4-(trifluoromethyl)phenyl)ethanamine
• 英文别名: (1S)-2,2,2-trifluoro-1-[4-(trifluoromethyl)phenyl]ethanamine
• CAS: 785766-87-2
• 化学式: C₉H₇F₆N
• 分子量: 243.15
• InChiKey: MSVVDWREITXLOD-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  7

安全信息

• 海关编码：
  2921499090

文献信息

• Transaminase reactions
  申请人：Codexis, Inc.

  公开号：US10138503B2

  公开（公告）日：2018-11-27

  The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.

  本公开涉及使用转氨酶多肽在合成手性胺类化合物中从原性酮中合成手性胺的方法。
• TRANSAMINASE REACTIONS
  申请人：Codexis, Inc.

  公开号：EP2446026A1

  公开（公告）日：2012-05-02
• EP2446026B1
  申请人：——

  公开号：EP2446026B1

  公开（公告）日：2017-08-09
• Transaminase Reactions
  申请人：Hughes Gregory

  公开号：US20120190085A1

  公开（公告）日：2012-07-26

  The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.
• ENGINEERED TRANSAMINASE POLYPEPTIDES AND USES THEREOF
  申请人：Enzymaster (Ningbo) Bio-Engineering Co., Ltd

  公开号：US20200332321A1

  公开（公告）日：2020-10-22

  Provided are amino acid sequences of engineered transaminase polynucleotide that are useful for asymmetrically synthesizing chiral amine compounds, and its preparation process and reaction process under industrial-relevant conditions. Also provided are polynucleotide sequences encoding engineered transaminase polypeptides, engineered host cells capable of expressing engineered transaminase polypeptides, and methods of producing chiral amine compounds using engineered transaminase polypeptides. Compared to other enzymes, the engineered transaminase polypeptides provided by this invention have better catalytic activity and stability, and are not inhibited by chiral amine products in the synthesis process. The use of the engineered polypeptides of the present invention for the preparation of chiral amine compound results in higher unit activity, and has good industrial application prospects.