(2,4,5-三氯苯基)丙-2-烯酸酯 | 40952-23-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 中文名称: (2,4,5-三氯苯基)丙-2-烯酸酯
• 英文名称: 2,4,5-trichlorophenyl acrylate
• 英文别名: trichlorophenyl acrylate；2,4,5-Trichlorphenylacrylat；(2,4,5-trichlorophenyl) prop-2-enoate
• CAS: 40952-23-6
• 化学式: C₉H₅Cl₃O₂
• 分子量: 251.496
• InChiKey: WPRNUAVQZCFEOA-UHFFFAOYSA-N

物化性质

• 熔点：
  64-65 °C
• 沸点：
  338.1±42.0 °C(Predicted)
• 密度：
  1.441±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,4,5-三氯苯酚 、 丙烯酰氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以67%的产率得到(2,4,5-三氯苯基)丙-2-烯酸酯
  参考文献：
  名称：

  Controlled Radical Polymerization of Active Ester Monomers:  Precursor Polymers for Highly Functionalized Materials

  摘要：

  DOI：

  10.1021/ma035876f

文献信息

• [EN] FORCE-RESPONSIVE POLYMERSOMES AND NANOREACTORS; PROCESSES UTILIZING THE SAME<br/>[FR] POLYMERSOMES ET NANORÉACTEURS SENSIBLES À LA FORCE; PROCÉDÉS LES UTILISANT
  申请人：ADOLPHE MERKLE INSTITUTE UNIV OF FRIBOURG

  公开号：WO2019034597A1

  公开（公告）日：2019-02-21

  The mechanically induced melting properties of DNA were employed to achieve force labile membranes is described. Nucleobase pairs were used as mechanophores. Adenine and thymine functionalized complementary amphiphilic block copolymers were self-assembled into polymersomes. The nucleobases formed hydrogen bonds which were disrupted upon force stimulation. The exposure of the disconnected nucleobases to the hydrophobic matrix of the membranes lead to a change of permeability which permitted the exchange of water-soluble molecules throughout the polymer matrix. Moreover, the encapsulation of horseradish peroxidase enabled the reaction of luminol with hydrogen peroxide to yield a luminescence producing species similar to the marine bioluminescence. Moreover, the same nano-reactors were employed to catalyze the formation of a polyacrylamide gel when force was applied. Insights into the change of permeability of supramolecular networks upon force are provided. These systems are useful for drug delivery, as nanoreactors and for the selective release of curing agents for 3D printing, or fragrances.

  DNA的机械诱导熔化特性被用来实现易受力破裂的膜。核碱基对被用作机械感受器。腺嘌呤和胸腺嘧啶功能化的互补两性分块共聚物自组装成聚合体囊。核碱基形成氢键，在受力刺激下被破坏。断开的核碱基暴露在膜的疏水基质中，导致渗透性的改变，从而允许水溶性分子在聚合物基质中交换。此外，封装辣根过氧化物酶使得辣根酰胺与过氧化氢反应产生类似海洋生物发光的发光物种。此外，当施加力时，相同的纳米反应器被用来催化聚丙烯酰胺凝胶的形成。提供了关于受力下超分子网络渗透性变化的见解。这些系统可用于药物传递、纳米反应器以及用于3D打印的固化剂或香料的选择性释放。
• Responsive microgel and methods related thereto
  申请人：——

  公开号：US20030152623A1

  公开（公告）日：2003-08-14

  A responsive microgel is provided which responds volumetrically and reversibly to a change in one or more aqueous conditions selected from the group consisting of (temperature, pH, and ionic conditions) comprised of an ionizable network of covalently cross-linked homopolymeric ionizable monomers wherein the ionizable network is covalently attached to an amphiphilic copolymer to form a plurality of ‘dangling chains’ and wherein the ‘dangling chains’ of amphiphilic copolymer form immobile micelle-like aggregates in aqueous solution. A responsive microgel is further provided that comprises at least one therapeutic entity and delivers a substantially linear and sustained release of the therapeutic entity under physiological conditions.

  本发明提供了一种响应型微凝胶，该微凝胶可对选自由温度、pH 值和离子条件组成的组中的一种或多种水性条件的变化作出体积上和可逆的响应、和离子条件）组成的共价交联均聚可离子化单体的可离子化网络，其中可离子化网络与两性共聚物共价连接，形成多条 "悬链"，两性共聚物的 "悬链 "在水溶液中形成不动的胶束状聚集体。还提供了一种响应性微凝胶，它包含至少一种治疗实体，并能在生理条件下提供治疗实体的线性和持续释放。
• Verfahren zur Herstellung von reaktiven, kupplungsfähigen Derivaten der Schilddrüsenhormone T3 und T4 und deren Verwendung
  申请人：BOEHRINGER MANNHEIM GMBH

  公开号：EP0049860B1

  公开（公告）日：1984-10-03
• PORE-SIZE SELECTIVE MODIFICATION OF POROUS MATERIALS
  申请人：CORNELL RESEARCH FOUNDATION, INC.

  公开号：EP0665867A1

  公开（公告）日：1995-08-09
• PORE-SIZE SELECTIVE CHEMICAL MODIFICATION OF POROUS MATERIALS
  申请人：CORNELL RESEARCH FOUNDATION, INC.

  公开号：EP0665867B1

  公开（公告）日：1998-01-07