(2,5-二氧代吡咯烷-1-基)4-肼基苯甲酸酯 | 133081-23-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (2,5-二氧代吡咯烷-1-基)4-肼基苯甲酸酯
• 中文别名: 琥珀酰亚氨基基4-肼基苯酸酯
• 英文名称: Succinimidyl 4-hydrazinobenzoate
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 4-hydrazinylbenzoate
• CAS: 133081-23-9
• 化学式: C₁₁H₁₁N₃O₄
• 分子量: 249.22
• InChiKey: FSWGOICFRWDKMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Monomethylvaline compounds capable of conjugation to ligands
  申请人：SEATTLE GENETICS, INC.

  公开号：US10414826B2

  公开（公告）日：2019-09-17

  Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.

  制备了金丝桃素肽，包括 MeVal-Val-Dil-Dap-Norephedrine (MMAE) 和 MeVal-Val-Dil-Dap-Phe (MMAF)，并通过马来酰亚胺基-val-cit-PAB 等各种连接体连接到配体上。所制备的配体药物共轭物在体外和体内均具有活性。
• MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS
  申请人：SEATTLE GENETICS, INC.

  公开号：US20180127512A1

  公开（公告）日：2018-05-10

  Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.