(2-溴-3-甲氧基苯基)氨基甲酸叔丁酯 | 809231-02-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (2-溴-3-甲氧基苯基)氨基甲酸叔丁酯
• 中文别名: 2-溴-3-甲氧基苯氨基甲酸叔丁酯
• 英文名称: (2-bromo-3-methoxyphenyl)carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-(2-bromo-3-methoxyphenyl)carbamate
• CAS: 809231-02-5
• 化学式: C₁₂H₁₆BrNO₃
• 分子量: 302.168
• InChiKey: OFFXYGJVQZFYKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-溴-3-甲氧基苯基)氨基甲酸叔丁酯 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 2-溴-3-甲氧基苯胺
  参考文献：
  名称：

  Discovery of novel potent and selective dipeptide hepatitis C virus NS3/4A serine protease inhibitors

  摘要：

  Starting from the previously reported HCV NS3/4A protease inhibitor BILN 2061 (1), we have used a fast-follower approach to identify a novel series of HCV NS3/4A protease inhibitors in which (i) the P3 amino moiety and its capping group have been truncated, (ii) a sulfonamide is introduced in the P1 cyclopropyl amino acid, (iii) the position 8 of the quinoline is substituted with a methyl or halo group, and (iv) the ring size of the macrocycle has been reduced to 14 atoms. SAR analysis performed with a limited set of compounds led to the identification of N-{17-[8-chloro-2-(4-isopropylthiazol-2-yl)-7-methoxyquinolin4-yloxy]-2,14-dioxo-3,15-diazatricyclo [13.3.0.0 [Bartenschlager, R.; Lohmann, V. J. Gen. Virol. 2000, 81, 1631; Vincent Soriano, Antonio Madejon, Eugenia Vispo, Pablo Labarga, Javier Garcia-Samaniego, Luz Martin-Carbonero, Julie Sheldon, Marcelle Bottecchia, Paula Tuma, Pablo Barreiro Expert Opin. Emerg. Drugs, 2008, 13, 1-19]]octadec-7-ene-4-carbonyl}(1-methylcyclopropyl)(1-methylcyclopropyl) sulfonamide 19l an extremely potent (K-i = 0.20 nM, EC50 = 3.7 nM), selective, and orally bioavailable dipeptide NS3/4A protease inhibitor, which has features attractive for further preclinical development. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.07.124
• 作为产物：
  描述：

  2-溴-3-甲氧基苯胺 在 4-二甲氨基吡啶 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 42.0h， 生成 (2-溴-3-甲氧基苯基)氨基甲酸叔丁酯
  参考文献：
  名称：

  Indole Synthesis by Controlled Carbolithiation of o-Aminostyrenes

  摘要：

  An effective synthesis of the functionalized indole ring system has been developed from substituted o-aminostyrene starting material. Our methodology involves a novel cascade reaction sequence of alkyllithium addition to the styrene double bond and subsequent trapping of the intermediate organolithium with a suitable electrophile, followed by an in situ ring closure and dehydration to generate the indole ring. This new reaction sequence allows for the introduction of molecular diversity at all positions on the indole scaffold. The procedure was shown to be successful with a range of both C and N substituents on the o-aminostyrenes. The reaction sequence was tolerant to the reactivity range of alkyllithiums such as tert-, sec-, and n-butyllithium. The electrophiles used were DMF, which generated indole products with C-2 unsubstituted, and nitriles, which incorporated the nitrile substituent at C-2. The o-aminostyrene starting materials were generated by a Pd-catalyzed cross-coupling reaction of a vinyl boronic acid equivalent with the readily available substituted o-bromoanilines.

  DOI：

  10.1021/jo048723e

文献信息

• 一种芳胺邻位取代的化合物的制备方法
  申请人：联化科技股份有限公司

  公开号：CN110396108A

  公开（公告）日：2019-11-01

  本发明公开了一种如式I所示的芳胺邻位取代的化合物的制备方法。本发明提供的制备方法，其包括如下步骤，步骤(1)、在连续流反应器中，将物料1和烷基锂试剂进行锂化反应；得到含如式III所示的金属锂化合物的溶液；所述的物料1为如式II所示的芳胺类化合物与有机溶剂的混合溶液；步骤(2)、在连续流反应器中，将物料2和步骤(1)中得到的含如式III所示的金属锂化合物的溶液进行偶联反应，得到如式I所示的芳胺邻位取代的化合物即可。采用本发明的制备方法可在室温下实现芳环上的锂化反应制备成相应的溴代、硼酸、醛、羧酸等产物，反应时间短，减少了易燃物料的和高反应活性中间体的在线量，提高了安全性。
• Indole Synthesis by Controlled Carbolithiation of <i>o</i>-Aminostyrenes
  作者：Albane Kessler、Claire M. Coleman、Patchanee Charoenying、Donal F. O'Shea

  DOI：10.1021/jo048723e

  日期：2004.11.1

  An effective synthesis of the functionalized indole ring system has been developed from substituted o-aminostyrene starting material. Our methodology involves a novel cascade reaction sequence of alkyllithium addition to the styrene double bond and subsequent trapping of the intermediate organolithium with a suitable electrophile, followed by an in situ ring closure and dehydration to generate the indole ring. This new reaction sequence allows for the introduction of molecular diversity at all positions on the indole scaffold. The procedure was shown to be successful with a range of both C and N substituents on the o-aminostyrenes. The reaction sequence was tolerant to the reactivity range of alkyllithiums such as tert-, sec-, and n-butyllithium. The electrophiles used were DMF, which generated indole products with C-2 unsubstituted, and nitriles, which incorporated the nitrile substituent at C-2. The o-aminostyrene starting materials were generated by a Pd-catalyzed cross-coupling reaction of a vinyl boronic acid equivalent with the readily available substituted o-bromoanilines.
• Discovery of novel potent and selective dipeptide hepatitis C virus NS3/4A serine protease inhibitors
  作者：Pierre Raboisson、Tse-I Lin、Herman de Kock、Sandrine Vendeville、Wim Van de Vreken、David McGowan、Abdellah Tahri、Lili Hu、Oliver Lenz、Frederic Delouvroy、Dominique Surleraux、Piet Wigerinck、Magnus Nilsson、Åsa Rosenquist、Bertil Samuelsson、Kenneth Simmen

  DOI：10.1016/j.bmcl.2008.07.124

  日期：2008.9

  Starting from the previously reported HCV NS3/4A protease inhibitor BILN 2061 (1), we have used a fast-follower approach to identify a novel series of HCV NS3/4A protease inhibitors in which (i) the P3 amino moiety and its capping group have been truncated, (ii) a sulfonamide is introduced in the P1 cyclopropyl amino acid, (iii) the position 8 of the quinoline is substituted with a methyl or halo group, and (iv) the ring size of the macrocycle has been reduced to 14 atoms. SAR analysis performed with a limited set of compounds led to the identification of N-17-[8-chloro-2-(4-isopropylthiazol-2-yl)-7-methoxyquinolin4-yloxy]-2,14-dioxo-3,15-diazatricyclo [13.3.0.0 [Bartenschlager, R.; Lohmann, V. J. Gen. Virol. 2000, 81, 1631; Vincent Soriano, Antonio Madejon, Eugenia Vispo, Pablo Labarga, Javier Garcia-Samaniego, Luz Martin-Carbonero, Julie Sheldon, Marcelle Bottecchia, Paula Tuma, Pablo Barreiro Expert Opin. Emerg. Drugs, 2008, 13, 1-19]]octadec-7-ene-4-carbonyl}(1-methylcyclopropyl)(1-methylcyclopropyl) sulfonamide 19l an extremely potent (K-i = 0.20 nM, EC50 = 3.7 nM), selective, and orally bioavailable dipeptide NS3/4A protease inhibitor, which has features attractive for further preclinical development. (C) 2008 Elsevier Ltd. All rights reserved.