(2-甲基-噻吩-3-基)-乙酸 | 30012-01-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 中文名称: (2-甲基-噻吩-3-基)-乙酸
• 英文名称: (2-methyl-thiophen-3-yl)-acetic acid
• 英文别名: (2-methyl-[3]thienyl)-acetic acid；(2-Methyl-[3]thienyl)-essigsaeure；2-methyl-3-thiopheneacetic acid；methyl 3-thiophene acetate；2-(2-methylthiophen-3-yl)acetic acid
• CAS: 30012-01-2
• 化学式: C₇H₈O₂S
• mdl: MFCD00297148
• 分子量: 156.205
• InChiKey: WLWMZUZOBOPULL-UHFFFAOYSA-N

物化性质

• 熔点：
  68.3-69.3 °C(Solv: hexane (110-54-3))
• 沸点：
  286.7±25.0 °C(Predicted)
• 密度：
  1.273±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  (2-甲基-噻吩-3-基)-乙酸 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 2-甲基-3-噻吩乙醇
  参考文献：
  名称：

  Rearrangements Involving 2-Thenylmagnesium Chloride

  摘要：

  DOI：

  10.1021/ja01152a112
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 吗啉 、 sulfur 作用下， 生成 (2-甲基-噻吩-3-基)-乙酸 、 (2-methyl-[3]thienyl)-glyoxylic acid
  参考文献：
  名称：

  Rearrangements Involving 2-Thenylmagnesium Chloride

  摘要：

  DOI：

  10.1021/ja01152a112

文献信息

• Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-kB activity and use thereof
  申请人：Sheppeck James

  公开号：US20060154973A1

  公开（公告）日：2006-07-13

  The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory- and immune-associated diseases, and have the structure including all stereoisomers thereof, tautomers thereof, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, wherein X is selected from N, O, and S; Y is N or CR 6 ; Z is a ring; and where R, R a , R b , R c , R d , R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.

  本发明涉及一类新的非甾体化合物，用于治疗与糖皮质激素受体、AP-1和/或NF-κB活性调节相关的疾病，包括肥胖、糖尿病、炎症和免疫相关疾病，并具有结构，包括其所有立体异构体、互变异构体或前药，或其药用可接受盐，其中X选自N、O和S；Y为N或CR6；Z为一个环；R、Ra、Rb、Rc、Rd、R1、R2、R3、R4和R5如本文所定义。还提供了包含所述化合物的药物组合物和治疗肥胖、糖尿病以及炎症或免疫相关疾病的方法。
• Thienopyridines useful as cardiovascular agents
  申请人：Ortho Pharmaceutical Corporation

  公开号：US04775757A1

  公开（公告）日：1988-10-04

  The synthesis of thienopyridine derivatives is described. The novel thienopyridine derivatives are cardiotonic agents and renal vasodilating agents. The compounds are useful as cardiovascular agents.

  描述了噻吩吡啶衍生物的合成。这些新型的噻吩吡啶衍生物是心效素和肾血管扩张剂。这些化合物可用作心血管药物。
• [EN] INTEGRATED ZWITTERIONIC CONJUGATED POLYMERS FOR BIOELECTRONICS, BIOSENSING, REGENERATIVE MEDICINE, AND ENERGY APPLICATIONS<br/>[FR] POLYMÈRES CONJUGUÉS ZWITTERIONIQUES INTÉGRÉS POUR APPLICATIONS DE BIOÉLECTRONIQUE, BIODÉTECTION, MÉDECINE RÉGÉNÉRATRICE ET ÉNERGIE
  申请人：CHENG GANG

  公开号：WO2015054484A1

  公开（公告）日：2015-04-16

  The present invention is directed to a versatile and high performance zwitterionic CP platform, which integrates all desired functions into one material. This zwitterionic CP consists of the conducting backbone and multifunctional zwitterionic side chains. Non-conducting zwitterionic materials gain electronic conductivity through the conducting backbone and CPs obtain excellent biocompatibility, sensitivity to environmental stimuli and controllable antifouling properties via multifunctional zwitterionic side chains. Unique properties from two distinct materials (conducting materials and zwitterionic materials) are integrated into one material without sacrificing any properties. This platform can potentially be adapted for a range of applications (e.g. bioelectronics, tissue engineering, wound healing, robotic prostheses, biofuel cell, etc.), which all require high performance conducting materials with excellent antifouling/biocompatibility at complex biointerfaces. This conducting material platform will significantly advance the development of conducting polymers in the field of biomedicine and biotechnology.

  本发明涉及一种多功能高性能的带正负离子的聚合物平台，将所有所需功能集成到一个材料中。这种带正负离子的聚合物由导电骨架和多功能带正负离子侧链组成。非导电的带正负离子材料通过导电骨架获得电子导电性，而聚合物通过多功能带正负离子侧链获得优异的生物相容性、对环境刺激的敏感性和可控的防污染性质。两种不同材料（导电材料和带正负离子材料）的独特性能被集成到一个材料中，而不会牺牲任何性能。这种平台可以潜在地适用于一系列应用（例如生物电子学、组织工程、伤口愈合、机器人假肢、生物燃料电池等），这些应用都需要具有优异的防污染/生物相容性的高性能导电材料在复杂的生物界面上。这种导电材料平台将显著推进导电聚合物在生物医学和生物技术领域的发展。
• Colorimetric glycopolythiophene biosensors
  申请人：The Regents of the University of California

  公开号：US20010026915A1

  公开（公告）日：2001-10-04

  The present invention relates to methods and compositions for the direct detection of analytes using observable spectral changes in biopolymeric systems. In particular, the present invention allows for the direct colorimetric detection of analytes using color changes that occur in glycopolythiophene polymer systems in response to selective binding of analytes.

  本发明涉及使用生物高分子系统中可观察到的光谱变化直接检测分析物的方法和组合物。特别地，本发明允许使用糖基聚硫苯聚合物系统中发生的颜色变化直接进行分析物的比色检测，以响应于分析物的选择性结合。
• INTEGRATED ZWITTERIONIC CONJUGATED POLYMERS FOR BIOELECTRONICS, BIOSENSING, REGENERATIVE MEDICINE, AND ENERGY APPLICATIONS
  申请人：THE UNIVERSITY OF AKRON

  公开号：US20160244554A1

  公开（公告）日：2016-08-25

  The present invention is directed to a versatile and high performance zwitterionic CP platform, which integrates all desired functions into one material. This zwitterionic CP consists of the conducting backbone and multifunctional zwitterionic side chains. Non-conducting zwitterionic materials gain electronic conductivity through the conducting backbone and CPs obtain excellent biocompatibility, sensitivity to environmental stimuli and controllable antifouling properties via multifunctional zwitterionic side chains. Unique properties from two distinct materials (conducting materials and zwitterionic materials) are integrated into one material without sacrificing any properties. This platform can potentially be adapted for a range of applications (e.g. bioelectronics, tissue engineering, wound healing, robotic prostheses, biofuel cell, etc.), which all require high performance conducting materials with excellent antifouling/biocompatibility at complex biointerfaces. This conducting material platform will significantly advance the development of conducting polymers in the field of biomedicine and biotechnology.

  本发明涉及一种多功能高性能的带正负电离的聚合物平台，将所有所需功能集成到一个材料中。这种带正负电离的聚合物由导电骨架和多功能带正负电离的侧链组成。非导电的带正负电离材料通过导电骨架获得电子导电性，聚合物通过多功能带正负电离的侧链获得优异的生物相容性、对环境刺激的敏感性和可控的抗污染性能。两种不同材料（导电材料和带正负电离材料）的独特性能被整合到一个材料中，而不会牺牲任何性能。这种平台可能适用于一系列应用（例如生物电子学、组织工程、伤口愈合、机器人假肢、生物燃料电池等），这些应用都需要具有优异的抗污染/生物相容性的高性能导电材料在复杂的生物界面上。这种导电材料平台将显著推进导电聚合物在生物医学和生物技术领域的发展。