(2-苯氧基乙基)(三苯基)溴化膦 | 22409-83-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (2-苯氧基乙基)(三苯基)溴化膦
• 中文别名: [2-(苯氧基)乙基]三苯基溴化鏻
• 英文名称: (2-phenoxyethyl)triphenylphosphonium bromide
• 英文别名: 2-(phenoxyethyl)triphenylphosphonium bromide；2-phenoxyethyltriphenylphosphonium bromide；<2-Phenoxy-ethyl>-triphenyl-phosphonium-bromid；(2-Phenoxy-ethyl)-triphenylphosphoniumbromid；2-Phenoxyethyltriphenylphosphonium-Ion；(2-Phenoxy-ethyl)-triphenyl-phosphonium-bromid；2-phenoxyethyl(triphenyl)phosphanium;bromide
• CAS: 22409-83-2
• 化学式: Br*C₂₆H₂₄OP
• 分子量: 463.354
• InChiKey: QFIVZQJPMLZRIS-UHFFFAOYSA-M

物化性质

• 熔点：
  103 °C
• 溶解度：
  可溶于二甲基亚砜；甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  2.06
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2931900090

反应信息

• 作为反应物：
  描述：

  (2-苯氧基乙基)(三苯基)溴化膦 在 sodium hydroxide 、 盐酸羟胺 、 sodium methylate 、 三乙胺 作用下， 以 甲醇 、 氯仿 、 苯 为溶剂， 反应 158.0h， 生成 triphenyl[2-(N-methoxyamino)ethyl]phosphonium iodide
  参考文献：
  名称：

  摘要：

  The reactions of phenylhydrazine and hydroxylamine with (beta-X-ethyl)triphenylphosphonium salts (X = Ph, Ph3P+Br-) (1, 2) afforded the corresponding beta-N-ethyl-substituted triphenylphosphonium salts (3, 4). The reaction of triphenyl(2-phenylhydrazinoethyl)phosphonium bromide 3 with an aqueous solution of NaOH in benzene afforded a statistical mixture of the cis and trans isomers of 2-(diphenylphosphoryl)acetaldehyde phenylhydrazone. (2-Hydroxyaminoethyl)triphenylphosphonium bromide reacted with sodium methoxide to give O-phosphobetaine.

  DOI：

  10.1023/a:1021372009930
• 作为产物：
  描述：

  2-苯氧乙基溴 、 三苯基膦 生成 (2-苯氧基乙基)(三苯基)溴化膦
  参考文献：
  名称：

  消除和加成反应。第十九部分。从β-取代的乙基苯基醚中消除酚盐：1,2-消除中活化的性质

  摘要：

  在对消除反应中活化性质的研究中，测量了碱性条件下一系列X-CH 2 ·CH 2 ·OPh类型的17种苯基醚中苯氧化物的消除速率。

  DOI：

  10.1039/j29700000671

文献信息

• Therapeutic agents
  申请人：KNOLL Aktiengesellschaft

  公开号：US05760035A1

  公开（公告）日：1998-06-02

  Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof in which R.sub.1, R.sub.2 and R.sub.3 independently represent hydrogen, hydroxy, halo, alkyl or alkoxy; ALK.sup.1 represents a C.sub.2-6 alkylene chain optionally substituted by one or more C.sub.1-2 alkyl groups; Y represents a piperidine ring which is attached through nitrogen to ALK.sup.1 ; R.sub.4 represents hydrogen or a C.sub.1-4 alkyl group; the broken line in --- represents a bond, or is absent and the free valency on Y is taken up by hydrogen and the free valency on CR.sub.4 is taken up by hydrogen or a C.sub.1-4 alkyl group; ALK.sup.2 is absent or represents a C.sub.1-4 alkylene chain optionally substituted by one or more C.sub.1-2 alkyl groups; and R.sub.5 and R.sub.6 independently represent hydrogen, alkyl, phenyl, alkyl (optionally substituted) or R.sub.5 and R.sub.6 together with the nitrogen atom to which they are attached represent a saturated 3-7 membered heterocyclic ring (with a proviso); are disclosed which are antiinflammatory, antiallergic and immunomodulatory agents. Compositions containing these compounds and processes to prepare these compounds are also disclosed.

  化合物的化学式如下 ##STR1## 及其药用盐，其中 R.sub.1、R.sub.2 和 R.sub.3 独立地代表氢、羟基、卤素、烷基或烷氧基；ALK.sup.1 代表一个 C.sub.2-6 烷基链，可选择地被一个或多个 C.sub.1-2 烷基基团取代；Y 代表通过氮原子连接到 ALK.sup.1 的哌啶环；R.sub.4 代表氢或一个 C.sub.1-4 烷基基团；--- 中的虚线代表键，或者不存在，Y 上的自由价被氢取代，CR.sub.4 上的自由价被氢或一个 C.sub.1-4 烷基基团取代；ALK.sup.2 不存在或代表一个 C.sub.1-4 烷基链，可选择地被一个或多个 C.sub.1-2 烷基基团取代；R.sub.5 和 R.sub.6 独立地代表氢、烷基、苯基、烷基（可选择地取代）或 R.sub.5 和 R.sub.6 与它们连接的氮原子一起代表饱和的 3-7 成员杂环环（附带条件）；这些化合物是抗炎、抗过敏和免疫调节剂。还披露了含有这些化合物的组合物以及制备这些化合物的方法。
• Certain 1,1-diaryl-propenyl-3-(1-pyrrolidino-2-carboxylic acids,
  申请人：——

  公开号：US04610995A1

  公开（公告）日：1986-09-09

  The invention provides a compound of the formula (I): ##STR1## or a salt, ester or amide thereof; wherein R.sub.1 is hydrogen or C.sub.1-4 alkyl and R.sub.2 is C.sub.1-4 alkyl substituted by a group R.sub.3 CO.sub.2 H or R.sub.1 and R.sub.2 taken together with the nitrogen comprise a nitrogen-containing heterocyclic ring having four to six ring members substituted by a group R.sub.3 CO.sub.2 H, wherein R.sub.3 is a C.sub.1-7 aliphatic hydrocarbon group or a single bond; R.sub.4 is hydrogen, halogen, hydroxy, cyano, C.sub.1-4 acyloxy, C.sub.1-4 alkoxy or C.sub.1-4 alkyl optionally substituted by one to three halogen atoms; X is --N.dbd. or --CH.dbd.; and A and B each represent hydrogen atoms or --CA--CB-- represents --C.dbd.C--. The invention also provides a method for the preparation of compounds of the formula (I), novel chemical intermediates in their preparation and pharmaceutical formulations. Compounds of the formula (I) have antihistaminic activity.

  本发明提供了一种式为（I）的化合物：##STR1## 或其盐、酯或酰胺；其中R.sub.1为氢或C.sub.1-4烷基，R.sub.2为C.sub.1-4烷基，其被R.sub.3 CO.sub.2 H基团取代，或R.sub.1和R.sub.2与氮一起构成含氮杂环环有四到六个环成员，该环被R.sub.3 CO.sub.2 H基团取代，其中R.sub.3为C.sub.1-7脂肪烃基或单键；R.sub.4为氢、卤素、羟基、氰基、C.sub.1-4酰氧基、C.sub.1-4烷氧基或C.sub.1-4烷基，可选地被一个到三个卤素原子取代；X为--N.dbd. 或--CH.dbd.；A和B分别代表氢原子或--CA--CB--代表--C.dbd.C--。本发明还提供了一种制备式（I）化合物的方法，以及其制备中的新型化学中间体和药物配方。式（I）的化合物具有抗组胺活性。
• Certain 3-amino-prop-1-enes for treating Trypanosoma cruzi infections
  申请人：Burroughs Wellcome Co.

  公开号：US03932663A1

  公开（公告）日：1976-01-13

  3-Amino-prop-1-enes substituted in the 1-position by various specified combinations of phenyl, biphenylyl and fluorenyl groups and optionally substituted in the amino group by alkyl or benzyl groups, which have been found to be active against infections of Trypanosoma cruzi. Methods of making such compounds and pharmaceutical formulations containing the same.

  本发明涉及在1-位置被苯基，联苯基和芴基组合的不同指定取代的3-氨基丙烯基，并在氨基中可选地被烷基或苄基取代的化合物，这些化合物已被发现对克鲁奇锥虫感染具有活性。制备这种化合物的方法以及包含它们的制药配方。
• 1,1-Diaryl-3-amino-prop-1-enes
  申请人：Burroughs Wellcome Co.

  公开号：US04079081A1

  公开（公告）日：1978-03-14

  3-Amino-prop-1-enes substituted in the 1-position by various specified combinations of phenyl, biphenylyl and fluorenyl groups and optionally substituted in the amino group by alkyl or benzyl groups, which have been found to be active against infections of Trypanosoma cruzi. Methods of making such compounds and pharmaceutical formulations containing the same.

  本发明涉及1-位置被苯基、联苯基和芴基组合的各种指定取代的3-氨基丙烯酸衍生物，以及选择性地在氨基上被烷基或苄基取代，这些衍生物已被发现对克鲁奇锥虫感染具有活性。本发明还涉及制备这些化合物的方法和含有这些化合物的制药配方。
• Novel Bicyclic Cannabinoids
  申请人：Makriyannis Alexandros

  公开号：US20070135388A1

  公开（公告）日：2007-06-14

  Bicyclic-cannabinoids and methods of preparation and use are presented. These compounds, when administered in a therapeutically effective amount to an individual or animal, results in a sufficiently high level of that compound in the individual or animal to cause a physiological response. The physiological response may be useful to treat a number of physiological conditions.

  本文介绍了双环大麻素及其制备和使用方法。当以治疗有效量的这些化合物给个体或动物注射时，会在个体或动物体内产生足够高的该化合物水平，从而引起生理反应。这种生理反应可能对治疗多种生理状况有用。