(20S)-孕甾烷-3alpha,20-二醇 | 28818-70-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: (20S)-孕甾烷-3alpha,20-二醇
• 中文别名: 2(1H)-吡啶酮,3-(氨基甲基)-4-甲基-6-苯基-
• 英文名称: pregnan-3 alpha-20-alpha-diol
• 英文别名: (20S)-Pregnane-3alpha,20-diol；(3R,8R,9S,10S,13S,14S,17S)-17-[(1S)-1-hydroxyethyl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS: 28818-70-4
• 化学式: C₂₁H₃₆O₂
• 分子量: 320.516
• InChiKey: YWYQTGBBEZQBGO-TUSLFBNQSA-N

物化性质

• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3α-acetoxy-5α-pregn-16-en-20-one 、 钠 、 盐酸 在 氯仿 、 magnesium sulfate 、 crude product 、 丙酮 作用下， 以 异丙醇 为溶剂， 反应 3.0h， 以gave 80 mg of a mixture (93:7) of 20α and 20β respectively的产率得到(20S)-孕甾烷-3alpha,20-二醇
  参考文献：
  名称：

  Methods, compositions, and compounds for allosteric modulation of the

  摘要：

  本发明涉及使用某些类固醇衍生物在新发现的γ-氨基丁酸受体-氯离子通道复合物上作用的位置，来调节大脑兴奋性以减轻压力、焦虑、失眠和癫痫活动的方法、组合物和化合物。

  公开号：

  US05591733A1

文献信息

• INFANT FEED AND METHOD
  申请人：MEDELA HOLDING AG

  公开号：US20170172167A1

  公开（公告）日：2017-06-22

  The present disclosure relates generally to a composition for feeding an infant. More particularly, the disclosure relates to a nutritional composition for feeding an infant comprising a stem-cell deficient first component and a second component comprising breast milk stem cells (BSCs). The second component is added to the first component, and the BSCs partially or fully replenish the stem-cell deficient first component with respect to BSCs. In some embodiments the first component is stem-cell deficient human breast milk and the second component comprises BSCs from the infant's mother's own milk. The compositions of the present disclosure have been developed primarily as a personalized, nutritional composition providing the beneficial effects of an infant's mother's own BSCs to the infant while not being able to receive the full benefits of being breastfed directly. The present disclosure also relates to a composition for feeding an infant and to processes of their production. In particular, the disclosure relates to a composition for feeding an infant comprising a first and a second component, wherein the first component provides the majority of the nutritional value to said composition, and wherein the second component comprises at least one live bacterium from human breast milk or the lactating human mammary gland. The disclosure has been developed primarily as a composition for feeding a mother's own infant, wherein the composition comprises processed human breast milk with a substantially reduced live bacterial cell count as compared to unprocessed breast milk but which at least one live bacterium, from the mother's own breast milk, is added such as to partially or fully replenish the processed human breast milk with respect to the at least one live bacterium. More particular, the composition is a personalised composition for feeding the mother's own preterm infant. The present invention also related to the combination of BSC and bacterial replenishment as described herein.
• US5084277A
  申请人：——

  公开号：US5084277A

  公开（公告）日：1992-01-28
• US5116619A
  申请人：——

  公开号：US5116619A

  公开（公告）日：1992-05-26
• US5591733A
  申请人：——

  公开号：US5591733A

  公开（公告）日：1997-01-07
• Methods, compositions, and compounds for allosteric modulation of the
  申请人：University of Southern California

  公开号：US05591733A1

  公开（公告）日：1997-01-07

  Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, insomnia and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-aminobutyric acid receptor-chloride ionophore (GR) complex.

  本发明涉及使用某些类固醇衍生物在新发现的γ-氨基丁酸受体-氯离子通道复合物上作用的位置，来调节大脑兴奋性以减轻压力、焦虑、失眠和癫痫活动的方法、组合物和化合物。