1,2-Diheptadecanoyl-sn-glycerol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1,2-Diheptadecanoyl-sn-glycerol
• 英文别名: [(2S)-2-heptadecanoyloxy-3-hydroxypropyl] heptadecanoate
• 化学式: C₃₇H₇₂O₅
• 分子量: 597.0
• InChiKey: RGROBSGNJZWWRZ-DHUJRADRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.1
• 重原子数：
  42
• 可旋转键数：
  36
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• COMPOSITIONS AND METHODS FOR ENHANCING CONTRAST IN IMAGING
  申请人：Marval Biosciences, Inc.

  公开号：EP2410990A1

  公开（公告）日：2012-02-01
• [EN] COMPOSITIONS AND METHODS FOR ENHANCING CONTRAST IN IMAGING<br/>[FR] COMPOSITIONS ET PROCÉDÉS D'AMÉLIORATION DES CONTRASTES EN IMAGERIE
  申请人：MARVAL BIOSCIENCES INC

  公开号：WO2010107990A1

  公开（公告）日：2010-09-23

  Examples of compositions of liposomes and methods of making the same containing high concentrations of contrast-enhancing agents for computed tomography are provided. Example compositions of such liposomes, when administered to a subject, provide for increased contrast of extended duration, as measured by computed tomography, in the bloodstream and other tissues of the subject. Also provided are example methods for making the liposomes stable, that is, resistant to leakage of the contrast-enhancing agents, including the extrusion of the liposomes at high pressures and at high flow rates per total pore area of the extrusion filters.