1,2-di-(13Z-docosenoyl)-sn-glycerol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1,2-di-(13Z-docosenoyl)-sn-glycerol
• 英文别名: [(2S)-2-[(Z)-docos-13-enoyl]oxy-3-hydroxypropyl] (Z)-docos-13-enoate
• 化学式: C₄₇H₈₈O₅
• 分子量: 733.2
• InChiKey: FZERQYTVWAKJPN-DZSRQPACSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  18.7
• 重原子数：
  52
• 可旋转键数：
  44
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• LIPOSOMAL COMPOSITIONS
  申请人：Nuvo Research GmbH

  公开号：US20130177629A1

  公开（公告）日：2013-07-11

  The present application includes liposomes and liposomal compositions that comprise chlorite, chlorate or a mixture thereof entrapped inside the liposome core, methods for their preparation and methods of use, in particular as medicaments.

  本申请涉及包括氯酸盐、氯酸盐或两者混合物被包裹在脂质体核内的脂质体和脂质体组成物，它们的制备方法和使用方法，特别是作为药物。
• Controlling translocation through nanopores with fluid walls
  申请人：The Regents of the University of Michigan

  公开号：US10254271B2

  公开（公告）日：2019-04-09

  Improved resolution and detection of nanoparticles are achieved when a nanopore connecting liquid compartments in a device running on the Coulter principle is provided with fluid coatings such as lipid walls. Fluid lipid walls are made of a lipid bilayer, and preferably include lipid anchored mobile ligands as part of the lipid bilayer. By varying the nature and concentration of the mobile ligand in the lipid bilayer, multifunctional coatings of lipids are provided.

  如果在根据库尔特原理运行的设备中，连接液体隔间的纳米孔具有流体涂层（如脂质壁），则可提高纳米粒子的分辨率和检测能力。流体脂质壁由脂质双分子层构成，最好包括脂质锚定移动配体作为脂质双分子层的一部分。通过改变脂质双分子层中可移动配体的性质和浓度，可提供多功能的脂质涂层。
• Nanopore-based determination of protein charge, shape, volume, rotational diffusion coefficient, and dipole moment
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US10317361B2

  公开（公告）日：2019-06-11

  Physical parameters of macromolecules are determined by measuring electrical current I over time for translocation events as the macromolecules in solution move between two liquid compartments that are separated by and fluidically coupled through a synthetic nanopore. Values of charge, volume, shape, rotational diffusion coefficient, and dipole moment are derived from the measurements.

  当溶液中的大分子在被合成纳米孔分隔和流体耦合的两个液室之间移动时，通过测量移位事件随时间变化的电流 I 来确定大分子的物理参数。电荷、体积、形状、旋转扩散系数和偶极矩的值都是通过测量得出的。
• Lipid-based drug carriers for rapid penetration through mucus linings
  申请人：The Johns Hopkins University

  公开号：US10556017B2

  公开（公告）日：2020-02-11

  Mucus-penetrating liposomal nanoparticles and methods of making and using thereof are described herein. The nanoparticles contain one or more lipids, one or more PEG-conjugated lipids, and optionally one or more additional materials that physically and/or chemically stabilize the particles. The nanoparticle have an average diameter of about 100 nm to about 300 nm, preferably from about 100 nm to about 250 nm, more preferably from about 100 nm to about 200 nm. The particles are mobile in mucus. The liposomes can further contain one or more therapeutic, prophylactic, and/or diagnostic agent to be delivered to a mucosal surface, such as the CV tract, the colon, the nose, the lungs, and/or the eyes. The liposomes can further contain one or more CEST agents to allow real time imaging of the particles in a live animal. The particles may also further contain an imaging agent, such as a fluorescent label.

  本文描述了粘液渗透脂质体纳米粒子及其制造和使用方法。纳米颗粒含有一种或多种脂质、一种或多种 PEG 结合的脂质，以及一种或多种物理和/或化学稳定颗粒的附加材料。纳米颗粒的平均直径约为 100 纳米至约 300 纳米，优选约 100 纳米至约 250 纳米，更优选约 100 纳米至约 200 纳米。颗粒在粘液中具有流动性。脂质体可进一步含有一种或多种治疗、预防和/或诊断药剂，以输送到粘膜表面，如CV道、结肠、鼻、肺和/或眼。脂质体可进一步含有一种或多种 CEST 剂，以便在活体动物体内对微粒进行实时成像。颗粒还可进一步含有成像剂，如荧光标签。
• Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof
  申请人：The Johns Hopkins University

  公开号：US10568975B2

  公开（公告）日：2020-02-25

  Surface conjugated diamagnetic Chemical Exchange Saturation Transfer (diaCEST) agent carriers and methods of making and using are described herein. The particles are safe alternatives to conventional paramagnetic or superparamagnetic metal-based MRI contrast agents that are often toxic and therefore not biocompatible. The carriers described herein can provide simultaneous monitoring of multiple particle types labeled with ‘multicolor’ diaCEST contrast agents. In some embodiments, the carriers are micro- and/or nanoparticles. In other embodiments, the carriers are liposomes. In some embodiments, the particles and/or liposomes are mucus penetrating. In other embodiments, the particles and/or liposomes are not mucus penetrating.

  本文描述了表面共轭二磁性化学交换饱和转移（diaCEST）剂载体及其制造和使用方法。这些粒子是传统顺磁性或超顺磁性金属磁共振成像造影剂的安全替代品，而传统的顺磁性或超顺磁性金属磁共振成像造影剂通常具有毒性，因此不具有生物相容性。本文所述的载体可同时监测多种用 "多色 "DiaCEST 造影剂标记的粒子类型。在某些实施方案中，载体是微型和/或纳米颗粒。在其他实施方案中，载体是脂质体。在某些实施方案中，颗粒和/或脂质体具有粘液穿透性。在其他实施方案中，微粒和/或脂质体不具有粘液穿透性。