(2E)-3-[3,4-二羟基-5-(4-丙-2-烯-1-基苯氧基)苯基]丙-2-烯醛 | 83864-77-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (2E)-3-[3,4-二羟基-5-(4-丙-2-烯-1-基苯氧基)苯基]丙-2-烯醛
• 英文名称: Obovatal
• 英文别名: (E)-3-[3,4-dihydroxy-5-(4-prop-2-enylphenoxy)phenyl]prop-2-enal
• CAS: 83864-77-1
• 化学式: C₁₈H₁₆O₄
• 分子量: 296.323
• InChiKey: KGHJODCHEIEYBP-HWKANZROSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2912499000

反应信息

• 作为反应物：
  描述：

  二氯甲烷 、 (2E)-3-[3,4-二羟基-5-(4-丙-2-烯-1-基苯氧基)苯基]丙-2-烯醛 在 sodium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 反应 2.5h， 生成 (E)-3-[7-(4-Allyl-phenoxy)-benzo[1,3]dioxol-5-yl]-propenal
  参考文献：
  名称：

  厚朴叶的厚朴叶和长卵形，新颖的联苯醚木脂素。

  摘要：

  从厚朴（Magnolia obovata THUNB.(通过化学和光谱研究，确定了它们的化学结构为 4'，5-二烯丙基-2，3-二羟基联苯醚和 3，4-二羟基-5-（烯丙基苯氧基）肉桂醛。前一种物质对致癌细菌变异链球菌具有抗菌活性，但活性低于 magnolol（5）和 honokiol（6）。

  DOI：

  10.1248/cpb.30.3347

文献信息

• Anticancer composition comprising obovatol or obovatal
  申请人：Kwon Byoung-Mog

  公开号：US20070037889A1

  公开（公告）日：2007-02-15

  Disclosed herein is an anticancer composition, comprising obovatol, represented by the following Chemical Formula 1, obovatal, represented by the following Chemical Formula 2, and/or pharmaceutical salts thereof. The composition exhibits the activity of inhibiting the growth of cancer cells and suppressing the expression and activity of matrix metalloproteinases (MMPs), and thus can be useful for the prophylaxis and treatment of cancer as well as for the inhibition of cancer metastasis.
• Anticancer Composition Comprising Obovatol or Obovatal
  申请人：KWON Byoung-Mog

  公开号：US20080312337A1

  公开（公告）日：2008-12-18

  Disclosed herein is an anticancer composition, comprising obovatol, represented by the following Chemical Formula 1, obovatal, represented by the following Chemical Formula 2, and/or pharmaceutical salts thereof. The composition exhibits the activity of inhibiting the growth of cancer cells and suppressing the expression and activity of matrix metalloproteinases (MMPs), and thus can be useful for the prophylaxis and treatment of cancer as well as for the inhibition of cancer metastasis.
• US8367736B2
  申请人：——

  公开号：US8367736B2

  公开（公告）日：2013-02-05
• [EN] THE PHARMACEUTICAL COMPOSITION OR THE FUNCTIONAL FOODS FOR THE TREATMENT OR PREVENTION OF OBESITY COMPRISING THE EXTRACT FROM MYRISTICA FRAGRANS HOUTTUYN<br/>[FR] COMPOSITION PHARMACEUTIQUE OU ALIMENTS FONCTIONNELS POUR LE TRAITEMENT OU LA PRÉVENTION DE L'OBÉSITÉ COMPRENANT L'EXTRAIT DE MYRISTICA FRAGRANS HOUTTUYN
  申请人：DONG WHA PHARM CO LTD

  公开号：WO2010064845A2

  公开（公告）日：2010-06-10

  There is provided a pharmaceutical composition and functional foods for the prevention and treatment of obesity, comprising an extract from Myristica fragrans Houttuyn as an effective component. The Myristica fragrans Houttuyn extract may be used for the pharmaceutical composition for the prevention and treatment of obesity caused by the intake of high-fat diets by suppressing an increase in body weights caused by the intake of high-fat diets, an increase in weights of periovarian fats and an accumulation of abdominal fats caused by the hypertrophy of adipocytes (fat cells). Furthermore, the extract from Myristica fragrans Houttuyn may be effectively used for the functional foods for the amelioration and prevention of obesity in humans including juveniles, adults and the old since it is used to ameliorate and prevent the obesity caused by the intake of high-fat diets.