(3E)-6-chloro-3-[(E)-1-(2-oxochromen-3-yl)ethylidenehydrazinylidene]-1H-indol-2-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: (3E)-6-chloro-3-[(E)-1-(2-oxochromen-3-yl)ethylidenehydrazinylidene]-1H-indol-2-one
• 化学式: C₁₉H₁₂ClN₃O₃
• 分子量: 365.8
• InChiKey: XGYPHJAMVBWLJK-LSHDLFTRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  80.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• LANTHIONINE SYNTHETASE COMPONENT C-LIKE PROTEINS AS MOLECULAR TARGETS FOR PREVENTING AND TREATING DISEASES AND DISORDERS
  申请人：Virginia Tech Intellectual Properties, Inc.

  公开号：EP2567225A2

  公开（公告）日：2013-03-13
• US9101573B2
  申请人：——

  公开号：US9101573B2

  公开（公告）日：2015-08-11
• [EN] LANTHIONINE SYNTHETASE COMPONENT C-LIKE PROTEINS AS MOLECULAR TARGETS FOR PREVENTING AND TREATING DISEASES AND DISORDERS<br/>[FR] PROTÉINES ANALOGUES AU COMPOSANT C DE LANTHIONINE SYNTHÉTASE COMME CIBLES MOLÉCULAIRES POUR PRÉVENTION ET TRAITEMENT DE MALADIES ET DE TROUBLES
  申请人：VIRGINIA TECH INTELL PROP

  公开号：WO2011140215A2

  公开（公告）日：2011-11-10

  The present invention relates to the field of medical treatments for diseases and disorders. More specifically, the present invention relates to the use of the lanthionine synthetase component C-like (LANCL) proteins as therapeutic targets for novel classes of anti-inflammatory, immune regulatory and antidiabetic drugs. This includes but it is not limited to abscisic acid (ABA), ABA analogs, benzimidazophenyls, repurposed drugs or drug combinations, including thiazolidinediones (TZDs); naturally occurring compounds such as conjugated diene fatty acids, conjugated triene fatty acids, isoprenoids, and natural and synthetic agonists of peroxisome proliferator- activated receptors that activate this receptor through an alternative mechanism of action involving LANCL2 or other membrane proteins to treat or prevent the common inflammatory pathogenesis underlying type 2 diabetes, atherosclerosis, cancer, some inflammatory infectious diseases such as influenza and autoimmune diseases including but not limited to inflammatory bowel disease (Crohn's disease and Ulcerative colitis), rheumatoid arthritis, multiple sclerosis and type 1 diabetes and other chronic inflammatory conditions.