(2S,5R,6R)-6-{[5-(乙酰基氨基)-5-羧酸根戊酰基]氨基}-3,3-二甲基-7-羰基-4-硫杂-1-氮杂二环[3.2.0]庚烷-2-羧酸二钠 | 84746-00-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 中文名称: (2S,5R,6R)-6-{[5-(乙酰基氨基)-5-羧酸根戊酰基]氨基}-3,3-二甲基-7-羰基-4-硫杂-1-氮杂二环[3.2.0]庚烷-2-羧酸二钠
• 英文名称: 1-oleoyl-2-acetyl-glycerol
• 英文别名: OAG；1-Oleoyl-2-acetylglycerol；(2-acetyloxy-3-hydroxypropyl) (Z)-octadec-9-enoate
• CAS: 84746-00-9
• 化学式: C₂₃H₄₂O₅
• 分子量: 398.583
• InChiKey: PWTCCMJTPHCGMS-KHPPLWFESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  28
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (2-acetyloxy-3-trityloxypropyl) (Z)-octadec-9-enoate 以90%的产率得到
  参考文献：
  名称：

  OGORODNIJCHUK, A. S.;SKRYMA, R. N.;BUDYGA, F. V.;PREVARSKAYA, N. B.;LUJK,+, YKP. XIM. ZH., 57,(1991) N, S. 327-329

  摘要：

  DOI：

文献信息

• Therapeutic use of of acyglycerols and the nitrogen-and sulphur-containing analogues thereof
  申请人：Darteil Raphael

  公开号：US20060252827A1

  公开（公告）日：2006-11-09

  The invention relates to the use of acylglycerols and the nitrogen- and sulfur-containing analogues thereof in therapy, particularly for the treatment of cerebral ischemia. The invention further relates to methods for preparing said derivatives, novel compounds, in particular acylglycerols, the nitrogen- and sulfur-containing analogues thereof and methods for preparing same.

  这项发明涉及在治疗中使用酰基甘油和其氮和硫含量类似物，特别是用于治疗脑缺血。该发明还涉及制备这些衍生物的方法，新颖化合物，特别是酰基甘油，其氮和硫含量类似物以及制备它们的方法。
• [EN] TRPC5 INHIBITORS AND METHODS OF USING SAME<br/>[FR] INHIBITEURS DE TRPC5 ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV NEBRASKA

  公开号：WO2019051197A1

  公开（公告）日：2019-03-14

  Provided herein are TRPC5 inhibitors and methods of using the same, e.g., to protect podocytes and/or treat kidney disease.

  本文提供了TRPC5抑制剂及其使用方法，例如用于保护足细胞和/或治疗肾脏疾病。
• METHOD AND SYSTEM FOR EFFECTING CHANGES IN PIGMENTED TISSUE
  申请人：Moazed Kambiz Thomas

  公开号：US20110280909A1

  公开（公告）日：2011-11-17

  Methods and systems are described for a rapid and sustainable change in the pigment melanin content of melanocytes of the iris stroma, thereby to change the color of the eye. Also described are nanoparticle compositions for lightening the pigmented tissues or treating a pigmented tissue related disease.

  描述了一种快速和可持续改变虹膜基质黑色素含量的黑色素细胞的方法和系统，从而改变眼睛的颜色。还描述了用于淡化有色组织或治疗有色组织相关疾病的纳米颗粒组合物。
• [EN] SUBSTITUTED 1,2,4-OXADIAZOLE, ITS APPLICATION AND A PHARMACEUTICAL PREPARATION COMPRISING IT<br/>[FR] 1,2,4-OXADIAZOLE SUBSTITUÉ, SON APPLICATION ET PRÉPARATION PHARMACEUTIQUE LE COMPRENANT
  申请人：SVENOX PHARMACEUTICALS LLC

  公开号：WO2020128675A1

  公开（公告）日：2020-06-25

  Substances effective against tuberculosis based on substituted 1,2,4-oxadiazoles of general formula I, where Y = S or CH2 and R = phenyl- or phenyl- substituted in positions 2, 3, 4, and 5 by one or several electron-acceptor groups or electron-donor groups. These compounds can be produced by easy syntheses and are characterized by low toxicity and high efficacy against mycobacteria, including multiresistant strains thereof. The invention also discloses a pharmaceutical preparation containing substituted 1,2,4-oxadiazole of formula I as active substance as well as the use of this substituted 1,2,4-oxadiazole as an antituberculosis drug.

  基于通式I的取代1,2,4-噁二唑，其中Y = S或CH2，R = 苯基或在2,3,4和5位上被一个或多个电子受体基团或电子给体基团取代的苯基。这些化合物可以通过简单的合成方法制备，并具有低毒性和高效抗结核分枝杆菌的特性，包括多重耐药菌株。本发明还揭示了一种含有通式I的取代1,2,4-噁二唑作为活性物质的药物制剂，以及将这种取代1,2,4-噁二唑用作抗结核药物的用途。
• [EN] 5-LIPOXYGENASE ANTAGONISTS<br/>[FR] ANTAGONISTES DE 5-LIPOXYGÉNASE
  申请人：INST DE MEDICINA MOLECULAR

  公开号：WO2019050422A1

  公开（公告）日：2019-03-14

  This invention relates to the treatment of conditions, such as cancer, associated with 5-lipoxygenase (5-LO) expression using β-lapachone compounds that inhibit 5-lipoxygenase (5-LO), such as β- lapachone and derivatives thereof. Methods of treatment of conditions associated with 5-lipoxygenase (5-LO) expression as well as medical uses of β-lapachone compounds in such methods are provided, as well as methods of selecting or prognosing cancer patients.

  本发明涉及使用β-落花松醌化合物治疗与5-脂氧合酶（5-LO）表达相关的疾病，如癌症，这些化合物抑制5-脂氧合酶（5-LO），如β-落花松醌及其衍生物。提供了治疗与5-脂氧合酶（5-LO）表达相关的疾病的方法以及β-落花松醌化合物在这种方法中的医疗用途，以及选取或预测癌症患者的方法。