(3,4-二甲氧基苯基)-(4-氟苯基)甲醇 | 844856-32-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (3,4-二甲氧基苯基)-(4-氟苯基)甲醇
• 英文名称: (3,4-dimethoxyphenyl)(4-fluorophenyl)methanol
• 英文别名: 4-Fluoro-3',4'-dimethoxybenzhydrol；(3,4-dimethoxyphenyl)-(4-fluorophenyl)methanol
• CAS: 844856-32-2
• 化学式: C₁₅H₁₅FO₃
• 分子量: 262.281
• InChiKey: YVYXGDYISKEXOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 危险类别码：
  R36/37/38
• 海关编码：
  2909499000

反应信息

• 作为反应物：
  描述：

  (3,4-二甲氧基苯基)-(4-氟苯基)甲醇 、 异丙醇 在 盐酸 作用下， 以 水 为溶剂， 反应 120.0h， 以100%的产率得到4-[(4-fluorophenyl)(isopropoxy)methyl]-1,2-dimethoxybenzene
  参考文献：
  名称：

  Hydrochloric acid as an efficient catalyst for intermolecular condensation of alcohols. A simple and highly efficient synthesis of unsymmetrical ethers from benzylic alcohols and alkanols

  摘要：

  Benzylic alcohols and diarylmethanols with electron-donating substituents in the aromatic ring reacted with aliphatic alcohols in the presence of a catalytic amount of HCl to give the corresponding alkyl arylmethyl ethers. The reactivity of diarylmethanols in the intermolecular dehydration depended on the nature of substituents in the aromatic rings and structure of aliphatic alcohol.

  DOI：

  10.1134/s107042801509002x
• 作为产物：
  描述：

  (3,4-二甲氧基苯基)(4-氟苯基)甲酮 在 sodium tetrahydroborate 作用下， 以88%的产率得到(3,4-二甲氧基苯基)-(4-氟苯基)甲醇
  参考文献：
  名称：

  Hydrochloric acid as an efficient catalyst for intermolecular condensation of alcohols. A simple and highly efficient synthesis of unsymmetrical ethers from benzylic alcohols and alkanols

  摘要：

  Benzylic alcohols and diarylmethanols with electron-donating substituents in the aromatic ring reacted with aliphatic alcohols in the presence of a catalytic amount of HCl to give the corresponding alkyl arylmethyl ethers. The reactivity of diarylmethanols in the intermolecular dehydration depended on the nature of substituents in the aromatic rings and structure of aliphatic alcohol.

  DOI：

  10.1134/s107042801509002x

文献信息

• Triflimide-catalyzed allylsilane annulations of benzylic alcohols for the divergent synthesis of indanes and tetralins
  作者：Jordan C. T. Reddel、Weiwei Wang、Kalli Koukounas、Regan J. Thomson

  DOI：10.1039/c6sc04762a

  日期：——

  development of a triflimide-catalyzed annulation of benzylic alcohols with allylsilanes for the synthesis of indane or tetralin structures is reported. In this fragment coupling reaction, complexity is built rapidly from readily available starting materials to yield diverse sets of products with up to three contiguous stereocenters. Indanes or tetralins can be generated from common precursors depending

  据报道，用三氟甲酰亚胺催化的苄醇与烯丙基硅烷的环合反应可用于茚满或四氢化萘结构的合成。在这种片段偶联反应中，从容易获得的起始原料迅速建立了复杂性，以产生具有多达三个连续立体中心的多种产品。取决于所使用的烯丙基硅烷试剂的结构，茚满或四氢化萘可以从常见的前体中生成。几种木脂素天然产物的简洁合成突显了这种新设计方法的实用性。
• [EN] BIOMASS-DERIVED PHOTOINITIATORS<br/>[FR] PHOTO-INITIATEURS DÉRIVÉS DE BIOMASSE
  申请人：BOWLING GREEN STATE UNIV

  公开号：WO2021236563A1

  公开（公告）日：2021-11-25

  Biomass derived benzophenone derivatives, and methods of making and using the same, are described. In accordance with the present disclosure, biomass derived benzophenone derivatives are useful as visible light photoinitiators.
• Hydrochloric acid as an efficient catalyst for intermolecular condensation of alcohols. A simple and highly efficient synthesis of unsymmetrical ethers from benzylic alcohols and alkanols
  作者：S. S. Mochalov、A. N. Fedotov、E. V. Trofimova、N. S. Zefirov

  DOI：10.1134/s107042801509002x

  日期：2015.9

  Benzylic alcohols and diarylmethanols with electron-donating substituents in the aromatic ring reacted with aliphatic alcohols in the presence of a catalytic amount of HCl to give the corresponding alkyl arylmethyl ethers. The reactivity of diarylmethanols in the intermolecular dehydration depended on the nature of substituents in the aromatic rings and structure of aliphatic alcohol.