2-(1H-benzimidazol-2-ylsulfanyl)-N'-[(E)-(4-hydroxy-3-methoxyphenyl)methylidene]acetohydrazide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-(1H-benzimidazol-2-ylsulfanyl)-N'-[(E)-(4-hydroxy-3-methoxyphenyl)methylidene]acetohydrazide
• 英文别名: 2-(1H-benzimidazol-2-ylsulfanyl)-N-[(E)-(4-hydroxy-3-methoxyphenyl)methylideneamino]acetamide
• 化学式: C₁₇H₁₆N₄O₃S
• 分子量: 356.4
• InChiKey: TWBUWRYKLIXUOO-GIJQJNRQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  129
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• CHEMICAL INHIBITORS OF SOLUBLE ADENYLYL CYCLASE (SAC)
  申请人：CORNELL RESEARCH FOUNDATION, INC.

  公开号：EP1706114B1

  公开（公告）日：2012-12-26
• Chemical Inhibitors of Soluble Adenylyl Cyclase (Sac)
  申请人：Buck Jochen

  公开号：US20070244174A1

  公开（公告）日：2007-10-18

  The present invention relates to a method of treating a disorder mediated by soluble adenylyl cyclase in a subject. The method involves administering to a subject an effective amount of a compound disclosed herein that modulates soluble adenylyl cyclase, under conditions effective to treat the disorder mediated by soluble adenylyl cyclase. The present invention also relates to a method of treating a disorder mediated by soluble adenylyl cyclase in a subject, where the disorder is selected from the group consisting of: learning or memory disorders, malaria, fungal infection, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, and peripheral neuropathy. The method involves modulating soluble adenylyl cyclase in the subject. Another aspect of the present invention relates to a method of modulating soluble adenylyl cyclase. The method involves contacting eukaryotic cells with a compound that modulates soluble adenylyl cyclase, under conditions effective to modulate soluble adenylyl cyclase.
• ADENYLYL CYCLASES AS NOVEL TARGETS FOR THE TREATMENT OF INFECTION BY EUKARYOTIC PATHOGENS
  申请人：Levin Lonny

  公开号：US20100063099A1

  公开（公告）日：2010-03-11

  The present invention relates to a method of preventing or treating a disease caused by infection by a eukaryotic pathogen, wherein the method comprises administering an effective amount of a modulator of a eukaryotic pathogen's adenylyl cyclase. The invention also provides pharmaceutical compositions useful for preventing or treating a disease, with the compositions containing a therapeutically effective amount of a modulator of a eukaryotic pathogen's adenylyl cyclase. The invention also provides screening methods for identifying selective modulators of a eukaryotic pathogen's adenylyl cyclase that do not substantially modulate an adenylyl cyclase of the subject. The invention also provides methods for culturing eukaryotic pathogens and methods for inducing the pathogenic state in vitro.
• US9095578B2
  申请人：——

  公开号：US9095578B2

  公开（公告）日：2015-08-04
• US9649295B2
  申请人：——

  公开号：US9649295B2

  公开（公告）日：2017-05-16