(3-硝基苯基)-(4-硝基苯基)-醚 | 2914-72-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (3-硝基苯基)-(4-硝基苯基)-醚
• 英文名称: 1-nitro-3-(4-nitrophenoxy)benzene
• 英文别名: (3-nitro-phenyl)-(4-nitro-phenyl)-ether；(3-Nitro-phenyl)-(4-nitro-phenyl)-aether；3.4'-Dinitro-diphenylaether；<3-Nitro-phenyl>-<4-nitro-phenyl>-ether
• CAS: 2914-72-9
• 化学式: C₁₂H₈N₂O₅
• mdl: MFCD00221998
• 分子量: 260.206
• InChiKey: RLCAMJXZACQENP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 海关编码：
  2909309090

反应信息

• 作为反应物：
  描述：

  (3-硝基苯基)-(4-硝基苯基)-醚 在 盐酸 、 tin 作用下， 生成 3,4'-二氨基二苯醚
  参考文献：
  名称：

  Iodo Derivatives of Diphenyl Ether. I. The Mono- and Certain Diiodo-Derivatives of Diphenyl Ether, and of 2- and 4-Carboxy Diphenyl Ethers¹

  摘要：

  DOI：

  10.1021/ja01316a035
• 作为产物：
  描述：

  对硝基二苯醚 以99%的产率得到
  参考文献：
  名称：

  XARADA, YUKA

  摘要：

  DOI：

文献信息

• CsF/clinoptilolite: an efficient solid base in S_NAr and copper-catalyzed Ullmann reactions
  作者：Hoda Keipour、Abolfazl Hosseini、Amir Afsari、Razieh Oladee、Mohammad A. Khalilzadeh、Thierry Ollevier

  DOI：10.1139/cjc-2015-0300

  日期：2016.1

  CsF/clinoptilolite was found to be an efficient solid base catalyst for both SNAr and Ullmann ether reactions. A general and efficient one-step procedure was developed for the synthesis of biaryl ethers via direct coupling of electron-deficient aryl halides to phenols using CsF/clinoptilolite. The protocol was also applied to electron-rich aryl halides by addition of a catalytic amount of copper oxide

  发现 CsF/斜发沸石是 SNAr 和 Ullmann 醚反应的有效固体碱催化剂。开发了一种通用且高效的一步法，通过使用 CsF/斜发沸石将缺电子的芳基卤化物直接偶联到酚类来合成联芳醚。该协议还通过添加催化量的氧化铜纳米粒子应用于富含电子的芳基卤化物。SNAr 和 Ullmann 反应都很快，并提供了良好的产率。
• Process and novel intermediate for the preparation of 3,4'-diaminodiphenyl ether
  申请人：Bromine Compounds Ltd.

  公开号：EP0477853A1

  公开（公告）日：1992-04-01

  In a process for the preparation of 3,4'-diaminodiphenyl ether, 3-nitrodiphenyl ether is reacted with a compound selected from Br2 and HN03 to yield a compound of the formula: wherein R is Br or N02; and then carrying out, in any appropriate order, the steps of: (a) substituting any Br atom in the 4'-position with an NH2 group; (b) reducing any N02 group to an NH2 group.

  在制备3,4'-二氨基二苯醚的过程中，将3-硝基二苯醚与Br2和HN03中选择的化合物反应，得到下式化合物：其中R为Br或N02; 然后按任何适当的顺序进行以下步骤：(a)用NH2基替换4'-位的任何Br原子；(b)将任何N02基还原为NH2基。
• The Formation of Aromatic Ethers from p-Nitrofluorobenzene
  作者：Morgan J. Rarick、R. Q. Brewster、F. B. Dains

  DOI：10.1021/ja01330a501

  日期：1933.3
• Preparation of Some Bis(nitrophenyl) Ethers, Bis(aminophenyl) Ethers, and Some Derived Azo Compounds¹
  作者：J. J. Randall、C. E. Lewis、P. M. Slagan

  DOI：10.1021/jo01058a532

  日期：1962.11
• Expression of human hepatitis C virus core antigen in tobacco plants by tobacco mosaic virus-based vector system
  作者：Aidong Han、Yule Liu、Li Xiao、Liangyi Kang、Yuman Zhang、Dongtian Li、Bo Tian

  DOI：10.1007/bf02884901

  日期：2000.3

  Tobacco mosaic virus (TMV) has the potential to highly express foreign gene. A novel TMV-based in trans expression system was constructed. A TMV mutant TSHc had its coat protein replaced with hepatitis C virus (HCV) core antigen gene. Another TMV mutant TSBD was replicase-detective. Coinfection of the two mutants could cause systemic infection in tobacco plants by in trans complementation of their functions. TSHc could effectively replicate and assemble to viral particles, which were a little longer than that of wild-type TMV. HCV core antigen was expressed in whole tobacco plants. A similar expression lever of HCV core antigen was detected on serial passages, which suggested that this viral expression system be stable.