己酮基维林盐酸盐

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 己酮基维林盐酸盐
• 英文名称: 2-[2-(Diethylamino)ethoxy]ethyl 1-phenylcyclopentane-1-carboxylate;hydron;chloride
• 英文别名: 2-[2-(diethylamino)ethoxy]ethyl 1-phenylcyclopentane-1-carboxylate;hydron;chloride
• 化学式: C20H32ClNO3
• 分子量: 369.9
• InChiKey: BNWCIGQOBYVGFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.82
• 重原子数：
  25
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  38.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Therapeutic approaches for treating parkinson's disease
  申请人：Pharnext

  公开号：EP2705842A1

  公开（公告）日：2014-03-12

  The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha-synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder.

  本发明涉及治疗帕金森病及相关疾病的组合物和方法。更具体地说，本发明涉及针对α-突触核蛋白聚集网络的帕金森病及相关疾病的新型组合疗法。特别是，本发明涉及可单独或以组合形式有效保护神经元细胞免受α-突触核蛋白聚集的化合物。本发明还涉及生产治疗帕金森病的药物或药物组合的方法，以及治疗帕金森病或相关疾病的方法。
• Therapeutic approaches for treating Parkinson's disease
  申请人：Pharnext

  公开号：US10004744B2

  公开（公告）日：2018-06-26

  The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha-synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder.

  本发明涉及治疗帕金森病及相关疾病的组合物和方法。更具体地说，本发明涉及针对α-突触核蛋白聚集网络的帕金森病及相关疾病的新型组合疗法。特别是，本发明涉及可单独或以组合形式有效保护神经元细胞免受α-突触核蛋白聚集的化合物。本发明还涉及生产治疗帕金森病的药物或药物组合的方法，以及治疗帕金森病或相关疾病的方法。
• Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level
  申请人：PHARNEXT

  公开号：US10092554B2

  公开（公告）日：2018-10-09

  The present invention relates to compositions and methods for controlling glycemia in a mammalian in need thereof. The present invention relates to compositions and methods for the treatment of diabetes and related disorders. More specifically, the present invention relates to novel therapies or combinatorial therapies for diabetes and related disorders, based on compositions controlling the blood glucose level.

  本发明涉及控制有需要的哺乳动物血糖的组合物和方法。本发明涉及治疗糖尿病及相关疾病的组合物和方法。更具体地说，本发明涉及基于控制血糖水平的组合物治疗糖尿病及相关疾病的新型疗法或组合疗法。
• SCHMELZEXTRUSION VON WIRKSTOFFSALZEN
  申请人：Röhm GmbH

  公开号：EP1478344B1

  公开（公告）日：2007-05-23
• EP2727587A1
  申请人：——

  公开号：EP2727587A1

  公开（公告）日：2014-05-07