(4-甲氧基苯基)甲基2-羟基苯甲酸酯 | 72845-81-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (4-甲氧基苯基)甲基2-羟基苯甲酸酯
• 英文名称: p-methoxybenzyl salicylate
• 英文别名: Benzoic acid, 2-hydroxy-, (4-methoxyphenyl)methyl ester；(4-methoxyphenyl)methyl 2-hydroxybenzoate
• CAS: 72845-81-9
• 化学式: C₁₅H₁₄O₄
• 分子量: 258.274
• InChiKey: YOKDOTYEULOJTI-UHFFFAOYSA-N

物化性质

• LogP：
  4.098 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-甲氧基苄醇 在 copper(l) chloride 作用下， 以 四氢呋喃 为溶剂， 生成 (4-甲氧基苯基)甲基2-羟基苯甲酸酯
  参考文献：
  名称：

  对甲氧基苄酯的简便制备

  摘要：

  摘要 在非常温和的条件下，使用预先形成的试剂 N,N-二异丙基-O-(4-甲氧基苄基)异脲可以方便有效地将羧酸作为对甲氧基苄酯进行保护，并且该方法可以选择性地保护羧酸中的羧酸。其他官能团的存在，例如可烯醇化的酮和醇基团。

  DOI：

  10.1080/00397910008087040

文献信息

• PERFUME PRECURSOR
  申请人：Takasago International Corporation

  公开号：EP3689849A1

  公开（公告）日：2020-08-05

  The present invention relates to a perfume precursor represented by formula (1). (In formula (1), R1 represents a hydrogen atom, a C1-C12 alkyl group, a hydroxy group, a methoxy group, or an ethoxy group; R2 represents a single bond, a C1-C2 alkylene group which may have a substituent, or a vinylene group which may have a substituent; R3 represents a residue obtained by removing one hydrogen atom of a hydroxy group from a C5-C20 perfume alcohol or a phenol which may have a substituent.)

  本发明涉及一种由式（1）表示的香水前体。(在式(1)中，R1 代表氢原子、C1-C12 烷基、羟基、甲氧基或乙氧基；R2 代表单键、可能具有取代基的 C1-C2 亚烷基或可能具有取代基的乙烯基；R3 代表通过从 C5-C20 香水醇或可能具有取代基的苯酚中去除羟基的一个氢原子而得到的残余物)。
• Catalytic Performance of Nano-SiO2-Supported Preyssler Heteropolyacid in Esterification of Salicylic Acid with Aliphatic and Benzylic Alcohols
  作者：Fatemeh F. BAMOHARRAM、Majid M. HERAVI、Javad EBRAHIMI、Ali AHMADPOUR、Mojtaba ZEBARJAD

  DOI：10.1016/s1872-2067(10)60219-7

  日期：2011.5

  An efficient and environmentally benign procedure for the catalytic esterification of salicylic acid with aliphatic alcohols, CnH2n+1OH (n = 1-5) and benzylic alcohols, RC6H4CH2OH (R = H, NO2, OCH3, Br, Cl, Me) was developed using nano-SiO2-supported Preyssler heteropolyacid both under thermal conditions and microwave irradiation. Silica nanostructures were obtained through a sol-gel method and were characterized by transmission electron microscopy and powder X-ray diffraction. The effects of various parameters such as solvent type, molar ratio of substrates, Preyssler heteropolyacid loading on silica, catalyst amount, temperature, and reaction time were studied and the optimum conditions were obtained. It has been found that the catalyst with 30 wt% loading is highly active and shows high yields in esterification reactions. The use of nano-SiO2-supported Preyssler heteropolyacid coupled with microwave irradiation allows a solvent-free, rapid (3 mm), and high-yielding reaction. This catalyst can be easily recovered and reused for many times without a significant loss in its activity.
• Esterification of Salicylic Acid Using Brønsted Acidic Ionic Liquid based on Keggin Heteropoly Acid
  作者：Fatemeh F. Bamoharram、Majid M. Heravi、Javad Ebrahimi、Nilofar Tavakoli-Hoseini

  DOI：10.1080/15533174.2013.768639

  日期：2014.1.2

  For the first time, a new water stable BrOnsted acidic ionic liquid based on Keggin heteroployacid (HPA) was used as environmentally benign catalytic medium in the esterfication of salicylic acid with aliphatic alcohols, CnH2n+1OH (n = 1-5) and benzylic alcohols, RC6H4CH2OH (R = H, NO2, OCH3). This ionic liquid (IL) afforded excellent yield in both thermal conditions and microwave irradiation. Maximum yields were observed under microwave irradiation. Different reaction runs were conducted by varying the reaction parameters such as molar ratio of reactants, weight of the IL, and reaction period in order to optimize the reaction. The IL was easily recovered and reused many times. No significant loss in catalytic activity was observed on recycling.
• A Convenient Preparation of<i>p</i>-Methoxybenzyl Esters
  作者：Meng F. Wang、Bernard T. Golding、Gerard A. Potter

  DOI：10.1080/00397910008087040

  日期：2000.12

  Abstract Carboxylic acids are conveniently and efficiently protected as their p-methoxybenzyl esters under very mild conditions using the pre-formed reagent N,N-diisopropyl-O-(4-methoxybenzyl)isourea, and this method allows selective protection of carboxylic acids in the presence of other functionalities such as enolisable ketones and alcohol groups.

  摘要 在非常温和的条件下，使用预先形成的试剂 N,N-二异丙基-O-(4-甲氧基苄基)异脲可以方便有效地将羧酸作为对甲氧基苄酯进行保护，并且该方法可以选择性地保护羧酸中的羧酸。其他官能团的存在，例如可烯醇化的酮和醇基团。